Описание: This book presents papers from the national conference on Applied Demography held in January 2010. It reflects the rapid change in contemporary applied demography and includes papers that deal with applied demography in Australia, Canada, Estonia, and Mexico.
Автор: Shigeo Sugimoto; Jane Hunter; Andreas Rauber; Atsu Название: Digital Libraries: Achievements, Challenges and Opportunities ISBN: 3540493751 ISBN-13(EAN): 9783540493754 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Constitutes the refereed proceedings of the 9th International Conference on Asian Digital Libraries, ICADL 2006, held in Kyoto, Japan in November 2006. This book features papers that include coverage of information extraction, information retrieval, metadata, architectures for digital libraries and archives, ontologies, and more.
Описание: Focuses on how global warming has caused an environmental disaster in the Arctic, namely its melting. This book offers insights on the issues that have grave implications for energy security and geopolitics in the arctic.
Автор: Walsh Название: Antibiotics: Challenges, Mechanisms, Opportunities ISBN: 1555819303 ISBN-13(EAN): 9781555819309 Издательство: Wiley Рейтинг: Цена: 16466.00 р. Наличие на складе: Поставка под заказ.
Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Автор: H.D. Perez; B. Mitrovic; A. Baron Van Evercooren Название: Opportunities and Challenges of the Therapies Targeting CNS Regeneration ISBN: 3642421482 ISBN-13(EAN): 9783642421488 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: New Strategies for CNS Repair.- Heterogeneity of Multiple Sclerosis: Implications for Therapy Targeting Regeneration.- The Neuroprotective Effect of Inflammation: Implications for the Therapy of Multiple Sclerosis.- Fibroblast Growth Factors in Oligodendrocyte Physiology and Myelin Repair.- White Matter Progenitor Cells Reside in an Oligodendrogenic Niche.- At the Interface of the Immune System and the Nervous System: How Neuroinflammation Modulates the Fate of Neural Progenitors In Vivo.- Remyelination and Restoration of Axonal Function by Glial Cell Transplantation.- Gene and Stem Cell Therapy for Autoimmune Demyelination.- Novel Gene Therapeutic Strategies for Neurodegenerative Diseases.- Measuring Injury and Repair of Myelin and Neurons in Multiple Sclerosis.
Addressing the complexities of radicalisation, resilience, cyber, and homeland security, State, Society and National Security: Challenges and Opportunities in the 21st Century aims to shed light on what has changed in recent years security discourse, what has worked (as well as what has not), and what the potential further evolutions within each domain might be.
The release of this book commemorates the 10th anniversary of the creation of the Centre of Excellence for National Security (CENS) -- a policy-oriented security think tank within the S Rajaratnam School for International Studies, Nanyang Technological University, as well as the 10th edition of CENS' annual Asia-Pacific Programme for Senior National Security Officers (APPSNO), which has developed into a premier international security conference in Southeast Asia.
Featuring contributions from practitioners, policy experts and academics closely linked to CENS, this volume is a reminder of the meaningful and impact-creating insights that 10 years' worth of thinking and talking about national security imperatives have generated.
Contributors to this volume include Professor Sir David Omand, former director of the United Kingdom's Government Communication Headquarters (GCHQ), Steven R Corman, Professor in the Hugh Downs School of Human Communication, Marc Sageman, former operations officer at the United States Central Intelligence Agency, Ilan Mizrahi, former Head of Israel's National Security Council and John, Lord Alderdice, Liberal Democrat member of the House of Lords and Senior Research Fellow and Director of the Centre for the Resolution of Intractable Conflict at Harris Manchester College, Oxford.
This book has been written in a manner that makes it accessible to policymakers, security practitioners and academics, as well as interested lay readers.
Описание: Among the places worst hit by climate change are areas of high urban growth in the warm, humid tropics of Asia and Latin America. In these places, the global trend of rapid urbanisation and conditions of local warming compound the effects of climate change.This three-part book explores the unique local climate consequences of urban growth trajectories of tropical cities and provides strategies and design approaches to enhance the quality of life of tropical urban dwellers in the face of urban warming. Part One considers the philosophical basis of the climate challenge in this context and investigates tropical urbanism from the viewpoints of urban activity patterns and the notion of 'thermal pleasure'. Part Two explores specific, practical techniques in enhancing ventilation, shading and greenery as well as the challenges in local climate assessment in the tropics. Part Three explores the barriers and future opportunities for climate-sensitive urban planning and presents specific examples of good practice, contextualized within the wider global debate on adapting to climate change. Urban Climate Challenges in the Tropics is an indispensable companion for planners, designers, architects and students of all levels.
Автор: Golosinski Название: Mining in the New Millennium - Challenges and Opportunities ISBN: 9058091805 ISBN-13(EAN): 9789058091802 Издательство: Taylor&Francis Рейтинг: Цена: 26030.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text concentrates mainly on the Polish mining industry. It involves mining of a significant quantities of lignite, coal, copper, sulphur and many industrial minerals, which are all discussed in this book.
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