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Medical Epigenetics, Trygve Tollefsbol


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Автор: Trygve Tollefsbol
Название:  Medical Epigenetics   (Тригве Толлефсбол: Медицинская эпигенетика)
Издательство: Elsevier Science
Классификация:
Медицинская генетика
Биологические науки: общие вопросы

ISBN: 0128032391
ISBN-13(EAN): 9780128032398
ISBN: 0-12-803239-1
ISBN-13(EAN): 978-0-12-803239-8
Обложка/Формат: Hardback
Страницы: 560
Вес: 2.806 кг.
Дата издания: 12.07.2016
Серия: Life Sciences
Язык: ENG
Иллюстрации: Illustrations
Размер: 225 x 283 x 50
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
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Поставляется из: Англии
Описание:

Medical Epigenetics is an inclusive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic disease that affect these systems, and modes of treating epigenetic-based disorders and diseases. This book provides stand-alone coverage of all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. It is useful not only to physicians, nurses, medical students, and many others directly involved with healthcare, but also investigators in life sciences, biotech companies, graduate students, and all others who are interested in more applied aspects of epigenetics.

The expansion of the field of epigenetics has brought a wealth of information with respect to variations in phenotypes that are heritable. In addition, many advances have emerged that have shown epigenetic aberrations as central to a number of diseases and disorders that were previously thought to be manifested primarily through genetic factors. Along with the remarkable studies that have been made in our understanding of epigenetic-based diseases and disorders has come new information that allows treatments that target these many epigenetic aberrations. Medical Epigenetics brings all of this knowledge together to comprehensively review the state of medical epigenetics in one defining volume.

The basic design of Medical Epigenetics is to lead the reader from the fundamental mechanisms of epigenetics as they apply to humans through approaches for treating epigenetic-based diseases. This book begins with the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics. Medical Epigenetics closes with a chapter on future prospects in medical epigenetics. This book is by far the most complete book in the area of applied epigenetics.
Focuses on practical and applied aspects of medical epigeneticsIncludes peer-reviewed chapters with up-to-date coverage of emerging topics in medical epigenetics by leading expertsAppeals to those interested in fundamental epigenetics and inheritance, as well as those with more clinical interests including practicing physicians and other health care professionalsCovers the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics

Дополнительное описание:




Epigenetics and Dermatology

Автор: Qianjin Lu
Название: Epigenetics and Dermatology
ISBN: 0128009578 ISBN-13(EAN): 9780128009574
Издательство: Elsevier Science
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Цена: 7569 р. 8410.00 -10%
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Описание: Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable.

Handbook of Epigenetics,

Автор: Trygve Tollefsbol
Название: Handbook of Epigenetics,
ISBN: 0123757096 ISBN-13(EAN): 9780123757098
Издательство: Elsevier Science
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Цена: 11024 р. 12249.00 -10%
Наличие на складе: Поставка под заказ.

Описание:

Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon.

This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.


  • Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications
  • Integrates methods and biological topics with basic and clinical discoveries
  • Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders
The Epigenetics of Autoimmune Diseases

Автор: Zouali
Название: The Epigenetics of Autoimmune Diseases
ISBN: 0470758619 ISBN-13(EAN): 9780470758618
Издательство: Wiley
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Цена: 15335 р.
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Описание: * Covers the latest discoveries and developments in epigenetics and their significance in a variety of autoimmune diseases including rheumatoid arthritis, autoimmune anaemia, type-1 diabetes, multiple sclerosis, autoimmune gastritis, thyroiditis, and systemic lupus erythematosus.

Brain, Behavior and Epigenetics

Автор: Petronis
Название: Brain, Behavior and Epigenetics
ISBN: 3642174256 ISBN-13(EAN): 9783642174254
Издательство: Springer
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Цена: 19224 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

Epigenetics of Aging

Автор: Tollefsbol
Название: Epigenetics of Aging
ISBN: 144190638X ISBN-13(EAN): 9781441906380
Издательство: Springer
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Цена: 19224 р.
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Описание: This seminal work covers the impact of epigenetics on aging, the epigenetics of age-related diseases, and future directions and perspectives on the epigenetics of aging. It covers the most recent advances that impact the longevity of living organisms.

Handbook of Epigenetics

Автор: Tollefsbol, Trygve
Название: Handbook of Epigenetics
ISBN: 0128053887 ISBN-13(EAN): 9780128053881
Издательство: Elsevier Science
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Цена: 14306 р. 15895.00 -10%
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Описание: Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. . The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.

Epigenetics: How Environment Shapes Our Genes

Автор: Francis Richard C.
Название: Epigenetics: How Environment Shapes Our Genes
ISBN: 039334228X ISBN-13(EAN): 9780393342284
Издательство: Wiley
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Цена: 1357 р.
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Описание: Goodbye, genetic blueprint. . . . The first book for general readers on the game-changing field of epigenetics.

Epigenetics

Название: Epigenetics
ISBN: 0520267095 ISBN-13(EAN): 9780520267091
Издательство: Wiley
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Цена: 8569 р.
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Описание: Illuminating the processes and patterns that link genotype to phenotype, this title seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene.

Epigenetics Protocols

Автор: Tollefsbol Trygve O.
Название: Epigenetics Protocols
ISBN: 158829336X ISBN-13(EAN): 9781588293367
Издательство: Springer
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Цена: 14492 р.
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Описание: A collection of state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer.

Translating Epigenetics to the Clinic

Автор: Laurence, Jeffrey
Название: Translating Epigenetics to the Clinic
ISBN: 0128008024 ISBN-13(EAN): 9780128008027
Издательство: Elsevier Science
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Цена: 6054 р. 6727.00 -10%
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Описание: Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. . Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole.

Stress and Epigenetics in Suicide

Автор: Rozanov, Vsevolod
Название: Stress and Epigenetics in Suicide
ISBN: 012805199X ISBN-13(EAN): 9780128051993
Издательство: Elsevier Science
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Цена: 3614 р. 4016.00 -10%
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Описание: Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. . It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. . This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention.

Epigenetics and Human Reproduction

Автор: Rousseaux
Название: Epigenetics and Human Reproduction
ISBN: 3642147720 ISBN-13(EAN): 9783642147722
Издательство: Springer
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Цена: 19224 р.
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Описание: Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction


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