Автор: Trygve Tollefsbol Название: Handbook of Epigenetics, ISBN: 0123757096 ISBN-13(EAN): 9780123757098 Издательство: Elsevier Science Рейтинг: Цена: 11024 р. 12249.00-10% Наличие на складе: Поставка под заказ.
Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon.
This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.
Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications
Integrates methods and biological topics with basic and clinical discoveries
Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders
Автор: Zouali Название: The Epigenetics of Autoimmune Diseases ISBN: 0470758619 ISBN-13(EAN): 9780470758618 Издательство: Wiley Рейтинг: Цена: 14735 р. Наличие на складе: Поставка под заказ.
Описание: * Covers the latest discoveries and developments in epigenetics and their significance in a variety of autoimmune diseases including rheumatoid arthritis, autoimmune anaemia, type-1 diabetes, multiple sclerosis, autoimmune gastritis, thyroiditis, and systemic lupus erythematosus.
Автор: Petronis Название: Brain, Behavior and Epigenetics ISBN: 3642174256 ISBN-13(EAN): 9783642174254 Издательство: Springer Рейтинг: Цена: 19224 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.
Автор: Tollefsbol Название: Epigenetics of Aging ISBN: 144190638X ISBN-13(EAN): 9781441906380 Издательство: Springer Рейтинг: Цена: 19224 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This seminal work covers the impact of epigenetics on aging, the epigenetics of age-related diseases, and future directions and perspectives on the epigenetics of aging. It covers the most recent advances that impact the longevity of living organisms.
Автор: Tollefsbol, Trygve Название: Handbook of Epigenetics ISBN: 0128053887 ISBN-13(EAN): 9780128053881 Издательство: Elsevier Science Рейтинг: Цена: 14306 р. 15895.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Francis Richard C. Название: Epigenetics: How Environment Shapes Our Genes ISBN: 039334228X ISBN-13(EAN): 9780393342284 Издательство: Wiley Рейтинг: Цена: 1253 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Goodbye, genetic blueprint. . . . The first book for general readers on the game-changing field of epigenetics.
Название: Epigenetics ISBN: 0520267095 ISBN-13(EAN): 9780520267091 Издательство: Wiley Рейтинг: Цена: 6166 р. Наличие на складе: Поставка под заказ.
Описание: Illuminating the processes and patterns that link genotype to phenotype, this title seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene.
Автор: Tollefsbol Trygve O. Название: Epigenetics Protocols ISBN: 158829336X ISBN-13(EAN): 9781588293367 Издательство: Springer Рейтинг: Цена: 14492 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A collection of state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer.
Автор: Qianjin Lu Название: Epigenetics and Dermatology ISBN: 0128009578 ISBN-13(EAN): 9780128009574 Издательство: Elsevier Science Рейтинг: Цена: 7569 р. 8410.00-10% Наличие на складе: Поставка под заказ.
Описание: Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable.
Автор: Laurence, Jeffrey Название: Translating Epigenetics to the Clinic ISBN: 0128008024 ISBN-13(EAN): 9780128008027 Издательство: Elsevier Science Рейтинг: Цена: 6054 р. 6727.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. . Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole.
Автор: Rozanov, Vsevolod Название: Stress and Epigenetics in Suicide ISBN: 012805199X ISBN-13(EAN): 9780128051993 Издательство: Elsevier Science Рейтинг: Цена: 3614 р. 4016.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Rousseaux Название: Epigenetics and Human Reproduction ISBN: 3642147720 ISBN-13(EAN): 9783642147722 Издательство: Springer Рейтинг: Цена: 19224 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction
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