Animal Models for Human Cancer: Discovery and Development of Novel Therapeutics, Marianne I. Martic–Kehl,Pius A. Schubiger,Raimund
Автор: David S. Ettinger; Ross Donehower (Eds.) Название: Current Cancer Therapeutics ISBN: 1573402850 ISBN-13(EAN): 9781573402859 Издательство: Springer Рейтинг: Цена: 18349 р. Наличие на складе: Поставка под заказ.
Описание: Presents the combined efforts of experts in pharmacologic oncology treatment. This book features summaries and charts of topics such as pharmacokinetics, drug indications, and toxicities. It provides protocols for treatment and supportive care of cancer patients. It is suitable for oncologists professionals involved in the treatment of cancer.
Описание: Combines two aspects, namely cancer research and the drug design and delivery from an integrated perspective of cancer treatment. This book describes various aspects of anticancer strategies and drug delivery approaches from different perspectives, including detailed discussion of several clinical trial cases.
Описание: Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity.
Описание: The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume stands as the first ever thematic volume in the series, focusing on the topic of genomics in cancer drug development. The chapters included in this book represent the cutting-edge information in the field and span such topics as Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics; Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches; The Application of siRNA Technology to Cancer Biology Discovery; Ribozyme Technology for Cancer Gene Target Identification and Validation; Cancer Cell-Based Genomic and Small Molecule Screens; Tumour Antigens as Surrogate Markers and Targets for Therapy and Vaccines; Practices and Pitfalls of Mouse Cancer Models in Drug Discovery; Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development – Quantification of Emerging Protein Biomarkers; Molecular Optical Imaging of Therapeutic Targets of Cancer; Cancer Drug Approval in the United States, Europe and Japan.
Описание: The urgent need for the development of early tumor diagnosis and effective anti-tumor therapies remains. This work intends to provide a relatively broad audience with a novel approach for the development of cancer diagnostics and targeted therapeutics. It offers coverage of various aspects of a selected domain of tumor immunology.
Описание: Gives an account of the sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians. This volume describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, and conducting and analyzing the results of clinical trials.
Описание: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Автор: Chorghade, Mukund S. Название: Drug discovery and development ISBN: 0471398462 ISBN-13(EAN): 9780471398462 Издательство: Wiley Рейтинг: Цена: 29288 р. Наличие на складе: Поставка под заказ.
Описание: This innovative two-volume set offers a unique, integrated presentation of the full spectrum of operations involved in drug discovery and development. The set covers the strategies, tactics, milestones, and benchmarks throughout the entire sequence of operations, from discovering a drug to prescribing it.
Описание: From principles to real-world applications, this is a guide to drug discovery and development. It describes various steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, and conducting and analyzing the results of clinical trials.
Описание: The book`s many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis.
Описание: This comprehensive review of existing and potential anticancer drugs and therapies by leading researchers from academia, government laboratories, and pharmaceutical companies offers essential insight into what has been accomplished and where the experimental therapy of cancer is going. The authoritative contributors illuminate the current status of the major molecules of cancer treatment, ranging from the nitrogen mustards through platinum complexes to interferons, cytokines, growth factors and their inhibitors, and on to immunotoxins, antisense oligonucleotides, and gene therapy. A companion volume by the same editor (Anticancer Drug Development Guide: Preclinical and Clinical Screening and Approval) details the processes by which new anticancer drugs are approved. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.
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