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It`s in Your DNA: From Discovery to Structure, Function and Role in Evolution, Cancer and Aging, Rosenberg, Eugene



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Цена: 3614р.   4016р. -10%
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Автор: Rosenberg, Eugene
Название:  It`s in Your DNA: From Discovery to Structure, Function and Role in Evolution, Cancer and Aging   (Эжен Розенберг: Это заложено в твоей ДНК)
Издательство: Elsevier Science
Классификация:
Онкология

ISBN: 0128125020
ISBN-13(EAN): 9780128125021
ISBN: 0-12-812502-0
ISBN-13(EAN): 978-0-12-812502-1
Обложка/Формат: Paperback
Страницы: 266
Вес: 0.364 кг.
Дата издания: 13.04.2017
Серия: Molecular Bio
Язык: ENG
Размер: 151 x 228 x 18
Читательская аудитория: Professional & vocational
Подзаголовок: From discovery to structure, function and role in evolution, cancer and aging
Ссылка на Издательство: Link
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Поставляется из: Англии
Описание: Its in Your DNA: From Discovery to Structure, Function and Role in Evolution, Cancer and Aging describes, in a clear, approachable manner, the progression of the experiments that eventually led to our current understanding of DNA. This fascinating work tells the whole story from the discovery of DNA and its structure, how it replicates, codes for proteins, and our current ability to analyze and manipulate it in genetic engineering to begin to understand the central role of DNA in evolution, cancer, and aging. . While telling the scientific story of DNA, this captivating treatise is further enhanced by brief sketches of the colorful lives and personalities of the key scientists and pioneers of DNA research. Major discoveries by Meischer, Darwin, and Mendel and their impacts are discussed, including the merging of the disciplines of genetics, evolutionary biology, and nucleic acid biochemistry, giving rise to molecular genetics. . After tracing development of the gene concept, critical experiments are described and a new biological paradigm, the hologenome concept of evolution, is introduced and described. The final two chapters of the work focus on DNA as it relates to cancer and gerontology. . This book provides readers with much-needed knowledge to help advance their understanding of the subject and stimulate further research. It will appeal to researchers, students, and others with diverse backgrounds within or beyond the life sciences, including those in biochemistry, genetics/molecular genetics, evolutionary biology, epidemiology, oncology, gerontology, cell biology, microbiology, and anyone interested in these mechanisms in life.
Дополнительное описание:




DNA Repair of Cancer Stem Cells

Автор: Mathews
Название: DNA Repair of Cancer Stem Cells
ISBN: 9400745893 ISBN-13(EAN): 9789400745896
Издательство: Springer
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Цена: 14854 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.

In Situ Detection of DNA Damage

Автор: Vladimir V. Didenko (Ed.)
Название: In Situ Detection of DNA Damage
ISBN: 1603274081 ISBN-13(EAN): 9781603274081
Издательство: Springer
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Цена: 15894 р.
Наличие на складе: Поставка под заказ.

Описание: Recent advances in organic chemistry, fluorescent microscopy, and materials science have created an entirely new range of techniques and probes for imaging DNA damage in molecular and cellular biology. In DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols, expert researchers explore the latest advances in the area, covering both recent and established techniques to detect and quantify DNA damage at scales ranging from subcellular to the level of a whole live organism. Chapters present all major assays used in molecular and cellular biology for the labeling of DNA damage in situ, ex vivo, and in vivo. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and current, DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols is an essential handbook for novice and experienced researchers in a variety of fields, including molecular and cellular biology, experimental and clinical pathology, toxicology, radiobiology, oncology, embryology, experimental pharmacology, drug design, and environmental science.

Free-Radical-Induced DNA Damage and Its Repair / A Chemical Perspective

Автор: Sonntag Clemens von
Название: Free-Radical-Induced DNA Damage and Its Repair / A Chemical Perspective
ISBN: 3540261206 ISBN-13(EAN): 9783540261209
Издательство: Springer
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Цена: 30583 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Both chemists and molecular biologists will find this an invaluable reference work for the study of free radical induced DNA damage and its repair.

Breast Cancer and Its Precursor Lesions

Автор: Patricia Thomas (Ed.)
Название: Breast Cancer and Its Precursor Lesions
ISBN: 1588296865 ISBN-13(EAN): 9781588296863
Издательство: Springer
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Цена: 15427 р.
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Описание: Rather than an exhaustive review of all the pathologic conditions of the female breast, Breast Cancer and its Precursor Lesions focuses on the current knowledge, understanding and issues related to breast cancer and its benign lesions that are associated with an increased risk for the subsequent development of cancer. This book targets the language, diagnostic terms and critical communication that must take place between primary care physicians, breast surgeons, oncologists, and general surgical pathologists interested in the pathologist’s perspective on these important diseases. The volume also reviews the current terminology and how to read or write meaningful pathology reports on these entities, the foils and nuances of the pathology and implications for management, and up to date issues in genomics and proteomics of these conditions. The text is succinct, fully informative, and written in “plain language”. All chapters are presented in a uniform fashion, and supplemented by high-quality illustrations and tables. Breast Cancer and its Precursor Lesions will be of great value to pathologists as well as primary care physicians, breast surgeons, and oncologists for understanding breast pathology and its implications for management.

DNA Repair in Cancer Therapy

Автор: Panasci Lawrence C., Alaoui-Jamali Moulay A.
Название: DNA Repair in Cancer Therapy
ISBN: 1588292983 ISBN-13(EAN): 9781588292988
Издательство: Springer
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Цена: 21412 р.
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Описание: A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

DNA Damage and Repair / Volume II: DNA Repair in Higher Eukaryotes

Автор: Nickoloff Jac A., Hoekstra Merl F.
Название: DNA Damage and Repair / Volume II: DNA Repair in Higher Eukaryotes
ISBN: 089603500X ISBN-13(EAN): 9780896035003
Издательство: Springer
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Цена: 24466 р.
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Описание: Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.

Oral Complications of Cancer and its Management (Hardback)

Автор: Davies, Andrew; Epstein, Joel
Название: Oral Complications of Cancer and its Management (Hardback)
ISBN: 0199543585 ISBN-13(EAN): 9780199543588
Издательство: Oxford Academ
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Цена: 9784 р.
Наличие на складе: Невозможна поставка.

Описание: Oral complications are hugely important for those treating cancer patients, either as an indication of disease or as a symptom of the disease. This is the first book to focus on this unique area of cancer care, providing international, evidence-based, clinical guidance for the whole team involved in treating the cancer patient with oral problems.

Cancer and Its Management

Автор: Tobias Jeffrey S
Название: Cancer and Its Management
ISBN: 1405170158 ISBN-13(EAN): 9781405170154
Издательство: Wiley
Рейтинг:
Цена: 6791 р.
Наличие на складе: Поставка под заказ.

Описание: Now in its sixth edition, this highly-regarded book is designed as an introductory text on the principles of diagnosis, staging and treatment of tumours. The new edition: Includes up-to-date information on the most recent techniques and therapies a

DNA Repair in Cancer Therapy,

Автор: Mark R. Kelley
Название: DNA Repair in Cancer Therapy,
ISBN: 0123849993 ISBN-13(EAN): 9780123849991
Издательство: Elsevier Science
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Цена: 9631 р.
Наличие на складе: Невозможна поставка.

Описание:

Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing discussion and research is centering on targeted and individualized therapy. While a number of approaches have undergone intensive and close scrutiny as potential approaches to treat and kill cancer (signaling pathways, multidrug resistance, cell cycle checkpoints, anti-angiogenesis, etc.), other approaches have focused on blocking the ability of a cancer cell to recognize and repair the damaged DNA that primarily results from the front-line cancer treatments; chemotherapy and radiation.

This comprehensive and timely reference focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.
Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on DNA repair and cancer therapy, as opposed to searching through thousands of journal articlesProvides a common language for cancer researchers, oncologists, and radiation oncologists to discuss their understanding of new molecular pathways, clinical targets, and anti-cancer drug developmentProvides content for researchers and research clinicians to understand the importance of the breakthroughs that are contributing to advances in disease-specific research

Gastroenteropancreatic System and Its Tumors: Part II, An Issue of Endocrinology and Metabolism Clinics,40-1

Автор: Aaron I. Vinik
Название: Gastroenteropancreatic System and Its Tumors: Part II, An Issue of Endocrinology and Metabolism Clinics,40-1
ISBN: 1455704407 ISBN-13(EAN): 9781455704408
Издательство: Elsevier Science
Рейтинг:
Цена: 8695 р.
Наличие на складе: Невозможна поставка.

Описание: Provides the endocrinologist with comprehensive updates about tumors of the gastroenteropancreatic system. This book covers topics including the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); and an update on incretins.

Gastroenteropancreatic System and Its Tumors: Part I, An Issue of Endocrinology Clinics,39-4

Автор: Aaron I. Vinik
Название: Gastroenteropancreatic System and Its Tumors: Part I, An Issue of Endocrinology Clinics,39-4
ISBN: 1437724477 ISBN-13(EAN): 9781437724479
Издательство: Elsevier Science
Рейтинг:
Цена: 7666 р.
Наличие на складе: Невозможна поставка.

Описание: Offers information about tumors of the gastroenteropancreatic system. This title covers such topics as: the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); and, chromogranins current state of the art, pathology of gastroenteropancreatic (GEP) disorders.

DNA Tumor Viruses

Автор: Blossom Damania; James Pipas (Eds.)
Название: DNA Tumor Viruses
ISBN: 0387689443 ISBN-13(EAN): 9780387689449
Издательство: Springer
Рейтинг:
Цена: 23374 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Focuses on the DNA viruses in the human population that are associated with cancers. This book covers most of the viruses that are thought to contribute to human malignancy. It presents a comprehensive review of the field of DNA tumor virology.


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