It`s in Your DNA: From Discovery to Structure, Function and Role in Evolution, Cancer and Aging, Rosenberg, Eugene
Автор: Mathews Название: DNA Repair of Cancer Stem Cells ISBN: 9400745893 ISBN-13(EAN): 9789400745896 Издательство: Springer Рейтинг: Цена: 14854 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
Автор: Vladimir V. Didenko (Ed.) Название: In Situ Detection of DNA Damage ISBN: 1603274081 ISBN-13(EAN): 9781603274081 Издательство: Springer Рейтинг: Цена: 15894 р. Наличие на складе: Поставка под заказ.
Описание: Recent advances in organic chemistry, fluorescent microscopy, and materials science have created an entirely new range of techniques and probes for imaging DNA damage in molecular and cellular biology. In DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols, expert researchers explore the latest advances in the area, covering both recent and established techniques to detect and quantify DNA damage at scales ranging from subcellular to the level of a whole live organism. Chapters present all major assays used in molecular and cellular biology for the labeling of DNA damage in situ, ex vivo, and in vivo. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and current, DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols is an essential handbook for novice and experienced researchers in a variety of fields, including molecular and cellular biology, experimental and clinical pathology, toxicology, radiobiology, oncology, embryology, experimental pharmacology, drug design, and environmental science.
Описание: Both chemists and molecular biologists will find this an invaluable reference work for the study of free radical induced DNA damage and its repair.
Автор: Patricia Thomas (Ed.) Название: Breast Cancer and Its Precursor Lesions ISBN: 1588296865 ISBN-13(EAN): 9781588296863 Издательство: Springer Рейтинг: Цена: 15427 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Rather than an exhaustive review of all the pathologic conditions of the female breast, Breast Cancer and its Precursor Lesions focuses on the current knowledge, understanding and issues related to breast cancer and its benign lesions that are associated with an increased risk for the subsequent development of cancer. This book targets the language, diagnostic terms and critical communication that must take place between primary care physicians, breast surgeons, oncologists, and general surgical pathologists interested in the pathologist’s perspective on these important diseases. The volume also reviews the current terminology and how to read or write meaningful pathology reports on these entities, the foils and nuances of the pathology and implications for management, and up to date issues in genomics and proteomics of these conditions. The text is succinct, fully informative, and written in “plain language”. All chapters are presented in a uniform fashion, and supplemented by high-quality illustrations and tables. Breast Cancer and its Precursor Lesions will be of great value to pathologists as well as primary care physicians, breast surgeons, and oncologists for understanding breast pathology and its implications for management.
Автор: Panasci Lawrence C., Alaoui-Jamali Moulay A. Название: DNA Repair in Cancer Therapy ISBN: 1588292983 ISBN-13(EAN): 9781588292988 Издательство: Springer Рейтинг: Цена: 21412 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.
Описание: Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.
Описание: Oral complications are hugely important for those treating cancer patients, either as an indication of disease or as a symptom of the disease. This is the first book to focus on this unique area of cancer care, providing international, evidence-based, clinical guidance for the whole team involved in treating the cancer patient with oral problems.
Автор: Tobias Jeffrey S Название: Cancer and Its Management ISBN: 1405170158 ISBN-13(EAN): 9781405170154 Издательство: Wiley Рейтинг: Цена: 6791 р. Наличие на складе: Поставка под заказ.
Описание: Now in its sixth edition, this highly-regarded book is designed as an introductory text on the principles of diagnosis, staging and treatment of tumours. The new edition: Includes up-to-date information on the most recent techniques and therapies a
Автор: Mark R. Kelley Название: DNA Repair in Cancer Therapy, ISBN: 0123849993 ISBN-13(EAN): 9780123849991 Издательство: Elsevier Science Рейтинг: Цена: 9631 р. Наличие на складе: Невозможна поставка.
Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing discussion and research is centering on targeted and individualized therapy. While a number of approaches have undergone intensive and close scrutiny as potential approaches to treat and kill cancer (signaling pathways, multidrug resistance, cell cycle checkpoints, anti-angiogenesis, etc.), other approaches have focused on blocking the ability of a cancer cell to recognize and repair the damaged DNA that primarily results from the front-line cancer treatments; chemotherapy and radiation.
This comprehensive and timely reference focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on DNA repair and cancer therapy, as opposed to searching through thousands of journal articlesProvides a common language for cancer researchers, oncologists, and radiation oncologists to discuss their understanding of new molecular pathways, clinical targets, and anti-cancer drug developmentProvides content for researchers and research clinicians to understand the importance of the breakthroughs that are contributing to advances in disease-specific research
Описание: Provides the endocrinologist with comprehensive updates about tumors of the gastroenteropancreatic system. This book covers topics including the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); and an update on incretins.
Описание: Offers information about tumors of the gastroenteropancreatic system. This title covers such topics as: the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); and, chromogranins current state of the art, pathology of gastroenteropancreatic (GEP) disorders.
Автор: Blossom Damania; James Pipas (Eds.) Название: DNA Tumor Viruses ISBN: 0387689443 ISBN-13(EAN): 9780387689449 Издательство: Springer Рейтинг: Цена: 23374 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Focuses on the DNA viruses in the human population that are associated with cancers. This book covers most of the viruses that are thought to contribute to human malignancy. It presents a comprehensive review of the field of DNA tumor virology.
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