Описание: This, the second volume in the series, provides a comprehensive collection of the cutting-edge methods making a major contribution to understanding the nucleus and its nanostructure today. Chapters contain tips for avoiding known pitfalls.
Автор: Ron C Conaway Название: Proteins in Eukaryotic Transcription,67 ISBN: 0120342677 ISBN-13(EAN): 9780120342679 Издательство: Elsevier Science Рейтинг: Цена: 21236 р. Наличие на складе: Поставка под заказ.
Описание: Protein Transcription is a key element of cellular and organ regulation. This volume covers structure and function of the major elements associated with transcription.
Описание: This text aims to offer comprehensive coverage of current transcription factor data in the field of experimental haematology and transcription factor biology. Written by established experts in the field, it offers a presentation of cell lineage development.
Автор: Semenza, Gregg L. Название: Transcription Factors and Human Disease ISBN: 0195112393 ISBN-13(EAN): 9780195112399 Издательство: Oxford Academ Рейтинг: Цена: 8133 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This work discusses the basic science of transcriptional regulation, and describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites.
Описание: Looks at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. This work applies molecular biology to transcriptional regulation of metabolism and obesity. It gives a theoretical background to understanding the strategies for potential therapeutic targets and their application to disease.
Описание: This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.
Автор: Hughes Название: A Handbook of Transcription Factors ISBN: 9048190681 ISBN-13(EAN): 9789048190683 Издательство: Springer Рейтинг: Цена: 30532 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
Автор: Higgins Название: Transcription Factors ISBN: 1607617374 ISBN-13(EAN): 9781607617372 Издательство: Springer Рейтинг: Цена: 23016 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Here, leading researchers describe the latest techniques for investigating the mechanisms underlying transcription factor nuclear-cytoplasmic trafficking, as well as the functional impact of post-translational modifications on transcription factor function.
Описание: Following this text's first edition a range of methodologies have been developed for studying isolated parts of the genome and the genome as a whole. This edition provides a comprehensive guide to the methods available to characterize the function and activity of an individual transcription factor.
Автор: Littlewood, Trevor D. (Imperial Cancer Research Fu Название: Helix-loop-helix Transcription Factors ISBN: 0198502486 ISBN-13(EAN): 9780198502487 Издательство: Oxford Academ Рейтинг: Цена: 17897 р. Наличие на складе: Поставка под заказ.
Описание: This volume explores the sequence specificity of DNA binding, the nature of dimerization partners, the regulation of target genes by HLH proteins, and the negative regulation of some bHLH proteins by HLH proteins which lack a functional DNA-binding domain.
Автор: Jeanteur Philippe Название: Epigenetics and Chromatin ISBN: 3540233725 ISBN-13(EAN): 9783540233725 Издательство: Springer Цена: 26729 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.
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