Rodrick Wallace; Deborah Wallace Gene Expression and Its Discontents 9783319480770

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Автор: Rodrick Wallace; Deborah Wallace
Название: Gene Expression and Its Discontents
ISBN: 9783319480770
Издательство: Springer
Классификация:

Эпидемиология и медицинская статистика

Медицинская генетика

Болезни и расстройства

Науки о жизни (медико-биологические): общие вопросы

ДНК и геном

Биохимия

ISBN-10: 3319480774
Обложка/Формат: Hardback
Страницы: 344
Вес: 0.70 кг.
Дата издания: 2017
Серия: Biomedicine
Язык: English
Издание: 2 rev ed
Иллюстрации: 52 black & white illustrations, 24 colour tables, biography
Размер: 234 x 156 x 21
Читательская аудитория: Professional & vocational
Подзаголовок: The social production of chronic disease
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.
Дополнительное описание: Introduction.- 1. Toward new tools.- 2. Models of development.- 3. Groupoid symmetries.- 4. Epigenetic catalysis.- 5. Developmental disorders.- 6. An interim perspective.- 7. The obesity pandemic in the US.- 8. Coronary heart disease in the US. - 9. Cance

Gene Expression and Its Discontents, Rodrick Wallace; Deborah Wallace