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Thyroid Hormone Disruption and Neurodevelopment, Noriyuki Koibuchi; Paul M. Yen


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Автор: Noriyuki Koibuchi; Paul M. Yen
Название:  Thyroid Hormone Disruption and Neurodevelopment
ISBN: 9781493937356
Издательство: Springer
Классификация:



ISBN-10: 1493937359
Обложка/Формат: Hardback
Страницы: 209
Вес: 0.50 кг.
Дата издания: 2017
Серия: Contemporary clinical neuroscience
Язык: English
Иллюстрации: 6 black & white illustrations, 16 colour illustrations, 19 colour tables, biography
Размер: 234 x 156 x 14
Читательская аудитория: General (us: trade)
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. ?
Дополнительное описание: Section 1: Disruption of thyroid hormone action at molecular level.- 1 Molecular mechanisms of thyroid hormone action in brain: a general overview.- 2 Deoidinases and brain development.- 3 Disruption of thyroid hormone receptor-mediated action in brain by



Thyroid Diseases

Автор: Monaco
Название: Thyroid Diseases
ISBN: 1439868387 ISBN-13(EAN): 9781439868386
Издательство: Taylor&Francis
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Цена: 18757.00 р. 26796.00 -30%
Наличие на складе: Есть (1 шт.)
Описание:

In recent years, the clinical evolution of thyroid diseases has been studied exhaustively as new discoveries have been made about thyroid malfunction and the effective management of patients. Thyroid Diseases presents a comprehensive exposition of a range of disorders caused by thyroid dysfunction. With contributions by well-known experts in the field, the book is the first compendium in several decades to assemble a vast amount of data and research into one volume.





Following a methodological format, each chapter explores a different malady or condition. After defining the dysfunction or disease, the text presents the epidemiology, etiopathogenesis, clinical features, first and second level tests for diagnosis, first and second line therapies, prognosis, and recommendations for follow-up.





Highlighted topics include:









  • Transient forms of hyper- and hypothyroidism


  • Subclinical hyper- and hypothyroidism


  • Thyroid dysfunction during gestation and postpartum


  • The influence of iodine on the thyroid during pregnancy


  • The importance of drugs that modify thyroid function


  • Thyroid disrupters that affect thyroid homeostasis


  • The bimodal and/or transient development of some thyroid diseases


  • The evolution of diagnosis, priorities of therapies, and lifelong monitoring of patients






All of the contributors to this text pursued long periods of training in elite research laboratories. They are active investigators and well known in the international arena. The information presented in this volume is invaluable for practicing clinicians and those training in internal medicine, endocrinology, surgery, and other areas of medicine.



Thyroid and Heart Failure

Автор: Giorgio Iervasi, Alessandro Pingitore
Название: Thyroid and Heart Failure
ISBN: 8847011426 ISBN-13(EAN): 9788847011427
Издательство: Springer
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Цена: 10760.00 р. 15372.00 -30%
Наличие на складе: Есть (1 шт.)
Описание: Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. This book presents the clinical, pathophysiological, and basic science aspects of thyroid - heart failure interactions.

Thyroid Cytopathology

Автор: Clark
Название: Thyroid Cytopathology
ISBN: 1441959521 ISBN-13(EAN): 9781441959522
Издательство: Springer
Рейтинг:
Цена: 13695.00 р. 19564.00 -30%
Наличие на складе: Есть (1 шт.)
Описание: These guide books fit into the lab coat pocket, ideal for portability and quick reference -- a must-have for every pathologist, cytopathologist, fellow and trainee. The inaugural volume is edited by two leaders in the field of thyroid cytopathology.

Surgery of the Thyroid and Parathyroid Glands

Автор: Oertli
Название: Surgery of the Thyroid and Parathyroid Glands
ISBN: 3540291652 ISBN-13(EAN): 9783540291657
Издательство: Springer
Цена: 18043.00 р. 25776.00 -30%
Наличие на складе: Есть (1 шт.)
Описание: The aim of this text is to create a unique in-depth comprehensive reference covering all surgically relevant thyroid and parathyroid diseases. It is a  definite reference presenting the latest information on the management of common and rare disorders of the thyroid and parathyroid glands. International authorities provide detailed discussions on operative techniques and treatments that are accompanied by rationales for particular approaches advocated by the authors. The topics include the description of all surgically relevant pathologies, the preoperative surgical evaluation, decision making, and operative strategies for the different thyroid and parathyroid diseases. In addition, experts present the molecular basis for thyroid neoplasia and the current understanding of the genetics of inherited thyroid and parathyroid diseases. Evolving modern operative techniques like the minimally invasive videoscopic approach to the thyroid and parathyroids are also covered.

Maternal Influences on Fetal Neurodevelopment

Автор: Zimmerman
Название: Maternal Influences on Fetal Neurodevelopment
ISBN: 1603279202 ISBN-13(EAN): 9781603279208
Издательство: Springer
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Цена: 24456.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume discusses many issues regarding neurodevelopmental disorders including ADHD, autism, schizophrenia, bipolar disorder and OCD. It explores common themes in prevention, treatment, and research issues surrounding fetal neurodevelopment.

Multi-System Endocrine Disruption

Автор: Jean-Pierre Bourguignon; Bernard J?gou; Bernard Ke
Название: Multi-System Endocrine Disruption
ISBN: 3642271030 ISBN-13(EAN): 9783642271038
Издательство: Springer
Рейтинг:
Цена: 26120.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Endocrine disruption is an expanding field due to the numerous chemicals involved and, as evidenced more recently, the variety of homeostatic systems that they can alter throughout life. The research needs have been discussed as well as recommendations prioritizing target groups and following the precautionary principle.

Hormone Resistence and Hypersensitivity States

Автор: Chrousos G.P.
Название: Hormone Resistence and Hypersensitivity States
ISBN: 0781714974 ISBN-13(EAN): 9780781714976
Издательство: Lippincott Williams & Wilkins
Цена: 17846.00 р.
Наличие на складе: Поставка под заказ.

Описание: Physiolical adaptations and pathological states resulting from changes oftarget tissue sensitivity to hormones are vital concerns in endocrinology. Part of the Modern Endocrinology series, this text features anoverview of the human hormone resistance and hypersensitivity syndromes due to pre-receptor, receptor and postreceptor abnormalities. The book focuses on the pivotal study of the etiology of common conditions, such as obesity andessential hypertension in chapters written by experts who have performedprimary research in hormone action.

Neurodevelopment and Adult Psychopathology

Автор: Keshavan
Название: Neurodevelopment and Adult Psychopathology
ISBN: 0521485657 ISBN-13(EAN): 9780521485654
Издательство: Cambridge Academ
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Цена: 16474.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Factors in the pathogenesis of the major psychiatric disorders are reviewed by an international group of experts in this 1997 book, covering neurodevelopment from the molecular to the behavioural level, clinical applications, and approaches toward a synthesis of neurodevelopmental and clinical findings in psychiatry.

Congenital Heart Disease and Neurodevelopment

Автор: McCusker, Christopher
Название: Congenital Heart Disease and Neurodevelopment
ISBN: 012801640X ISBN-13(EAN): 9780128016404
Издательство: Elsevier Science
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Цена: 11620.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes brings together the work of leading researchers from the U.K., Europe, and the U.S. to provide a comprehensive examination of the causes, risks, and neurodevelopmental and psychological outcomes in children with congenital heart disease. The book includes longitudinal studies which have tracked outcomes from birth through late childhood and explores the emergent phenotype and etiologies, risk, and protective factors that strengthen proposed models.

Medical and surgical advances have meant that greater numbers of children with even the most severe congenital heart disease (CHD) now survive well into adulthood. Studies over the past 20 years have suggested certain neurodevelopmental and psychological features are common, with clinical interventions being internationally articulated. The U.K. Belfast Center has developed and evaluated unique early intervention programs to circumvent the common problems discerned and promote optimal adjustment and outcomes. The first edition of Neurodevelopmental and Psychological Phenotypes in Children with Congenital Heart Disease describes these programs in detail and outlines promising results obtained by researchers worldwide. Such interventions, together with the U.S. consensus statement (Circulation, 2012) on neurodevelopmental screening, hold great promise for clinical interventions.

  • Features input from leading research experts in the field
  • Describes cutting-edge research on longitudinal studies that link neurodevelopmental phenotypes with cutting edge neuroimaging studies
  • Discusses the first series of early intervention studies developed in Belfast targeted at key developmental transitions-birth and diagnosis, early childhood, and adolescence
  • Includes clinical implications and action points in each section
  • Features generalizable potential of interventions across other pediatric populations

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