Modern Adaptive Randomized Clinical Trials 9781482239881

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Название: Modern Adaptive Randomized Clinical Trials
ISBN: 9781482239881
Издательство: Taylor&Francis
Классификация:

Клинические испытания

Эпидемиология и медицинская статистика

Фармакология

ISBN-10: 1482239884
Обложка/Формат: Hardback
Страницы: 533
Вес: 0.94 кг.
Дата издания: 07.07.2015
Серия: Chapman & hall/crc biostatistics series
Язык: English
Иллюстрации: 52 tables, black and white; 45 illustrations, black and white
Размер: 244 x 164 x 35
Читательская аудитория: Tertiary education (us: college)
Ключевые слова: Epidemiology & medical statistics, MATHEMATICS / Probability & Statistics / General,MEDICAL / Biostatistics,MEDICAL / Pharmacology
Основная тема: Medical Statistics & Computing
Подзаголовок: Statistical and practical aspects
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание: Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and unbiased treatment comparisons following adaptive randomization designs? Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects answers these questions and more. From novel designs to cutting-edge applications, this book presents several new and key developments in adaptive randomization. It also offers a fresh and critical look at a number of already-classical topics. Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and the pharmaceutical industry, the text: Clarifies the taxonomy of the concept of adaptive randomization Discusses restricted, covariate-adaptive, response-adaptive, and covariate-adjusted response-adaptive (CARA) randomization designs, as well as randomized designs with treatment selection Gives an exposition to many novel adaptive randomization techniques such as brick tunnel randomization, targeted least absolute shrinkage and selection operator (LASSO)-based CARA randomization, multi-arm multi-stage (MAMS) designs, to name a few Addresses the issues of statistical inference following covariate-adaptive and response-adaptive randomization designs Describes a successful implementation of a single pivotal phase II/III adaptive trial in infants with proliferating hemangioma Explores some practical aspects of phase II dose-ranging studies and examines statistical monitoring and interim analysis issues in response-adaptive randomized clinical trials Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects covers a wide spectrum of topics related to adaptive randomization designs in contemporary clinical trials. The book provides a thorough exploration of the merits of adaptive randomization and aids in identifying when it is appropriate to apply such designs in practice.

Modern Adaptive Randomized Clinical Trials,