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Three-Dimensional Electron Microscopy of Macromolecular Assemblies Visualization of Biological Molecules in their Native State (Hardback), Frank, Joachim



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Автор: Frank, Joachim
Название:  Three-Dimensional Electron Microscopy of Macromolecular Assemblies Visualization of Biological Molecules in their Native State (Hardback)
ISBN: 9780195150964
Издательство: Oxford Academ
Классификация:
ISBN-10: 0195150961
Обложка/Формат: Hardback
Страницы: 400
Вес: 0.775 кг.
Дата издания: 01.10.2005
Язык: English
Издание: New ed
Иллюстрации: Numerous halftones, line drawings and mathematical examples
Размер: 243 x 161 x 24
Читательская аудитория: Professional & vocational
Основная тема: Cellular biology
Подзаголовок: Visualization of biological molecules in their native state
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Англии



Three-dimensional electron microscopy of macromolecular assemblies

Автор: Frank, Joachim
Название: Three-dimensional electron microscopy of macromolecular assemblies
ISBN: 0195182189 ISBN-13(EAN): 9780195182187
Издательство: Oxford Academ
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Цена: 15407 р.
Наличие на складе: Поставка под заказ.

Описание: In the past ten years there has been a tremendous surge in applications of cryo-electron microscopy in the study of macromolecular assemblies, in especially those in single-particle form. Although the path toward atomic resolution is much more tedious than in electron crystallography of two-dimensional crystals, realization of such resolution for entirely asymmetrical molecules is now in close reach. In Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State, Joachim Frank describes the mathematical principles and working methods of single-particle reconstruction--a method designed to retrieve structural information from electron micrographs showing many "copies" of molecules trapped in ice in random orientations. The technique is uniquely suited to obtain three-dimensional images of molecular machines in different functional states, as it does not require crystals. This revised edition includes a basic introduction to transmission electron microscopy and the design of the instruments, and it covers specimen preparation in greater depth. Frank addresses the remarkable convergence of processing methods that has taken place, making it possible to sharpen the focus of some sections. New sections have been added that cover segmentation as well as various techniques of docking and fitting. Finally, appendix material is now included; this tabulates applications and methods of single-particle reconstruction and describes the most important mathematical tools and theorems of Fourier processing.

Conformational proteomics of macromolecular architecture: approaching the structure of large molecular assemblies and their mechanisms of action (with cd-rom)

Автор: Cheng Holland R & Hammar Lena
Название: Conformational proteomics of macromolecular architecture: approaching the structure of large molecular assemblies and their mechanisms of action (with cd-rom)
ISBN: 9812386157 ISBN-13(EAN): 9789812386151
Издательство: World Scientific Publishing
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Цена: 8765 р.
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Описание: Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which "activity" can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation will be explored as it applies to the static quasisymmetry situations, as well as to the dynamics of structural transitns. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this work presents knowledge in the various fields of structural proteomics of very large molecular assemblies, with focus on their mechanisms of action.

Conformational proteomics of macromolecular architecture: approaching the structure of large molecular assemblies and their mechanisms of action (with cd-rom)

Название: Conformational proteomics of macromolecular architecture: approaching the structure of large molecular assemblies and their mechanisms of action (with cd-rom)
ISBN: 9812386149 ISBN-13(EAN): 9789812386144
Издательство: World Scientific Publishing
Рейтинг:
Цена: 11778 р.
Наличие на складе: Поставка под заказ.

Описание: Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which "activity" can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct.

The biological implications of such adaptation will be explored as it applies to the static quasisymmetry situations, as well as to the dynamics of structural transitions. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this work presents knowledge in the various fields of structural proteomics of very large molecular assemblies, with focus on their mechanisms of action.


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