Bulayeva Genomic Architecture of Schizophrenia Across Diverse Genetic Isolates 9783319319629

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Автор: Bulayeva
Название: Genomic Architecture of Schizophrenia Across Diverse Genetic Isolates
ISBN: 9783319319629
Издательство: Springer
Классификация:

Социальная и культурная антропология, этнография

Медицинская генетика

Науки о жизни (медико-биологические): общие вопросы

Генетика (немедицинская)

Нейронауки

ISBN-10: 3319319620
Обложка/Формат: Hardback
Страницы: 142
Вес: 0.43 кг.
Дата издания: 2016
Язык: English
Издание: 2016 ed.
Иллюстрации: 15 black & white illustrations, 35 colour illustrations, 22 colour tables, biography
Размер: 234 x 156 x 11
Читательская аудитория: General (us: trade)
Основная тема: Biomedicine
Подзаголовок: A Study of Dagestan Populations
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.
Дополнительное описание: 1 Current Problems of Complex Disease Genes Mapping.- 2 Descriptions and Methods of Study in Selected Genetic Isolates of Dagestan.- 3 Selection of Populations for Mapping Genes of Complex Diseases.- 4 Mapping Genes of Schizophrenia in Selected Dagestan I

Genomic Architecture of Schizophrenia Across Diverse Genetic Isolates, Bulayeva