Osteoporosis in Older Persons, Duque, Gustavo, Kiel, Douglas P.
Автор: Reiner Bartl; Bertha Frisch Название: Osteoporosis ISBN: 354079526X ISBN-13(EAN): 9783540795261 Издательство: Springer Рейтинг: Цена: 13275.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book covers everything from basic physiology to osteoporosis diagnosis, including utility of specialized tests and current treatment recommendations, and will provide the primary care physician with sound medical knowledge in the prevention and management of osteoporosis.
Описание: The term Vitamin D designates a group of closely related seco-steroids with antirachitic activity. The two most important members of these are ergocalciferol
(vitamin D2) and cholecalciferol (vitamin D3). About 80 per cent of the vitamin D supply in man is produced in the skin and only 20 per cent is provided by nutrition.
The first
analogue of Vitamin D, dihydrotachysterol, was developed in the 1930s and used in the treatment of primary or secondary hypoparathyroidism. It then took 40 years to learn that Vitamin
D was not the biologically active principle for healing bone disease. It has to be hydroxylated in the liver at position 25 to build 25-hydroxycholecalciferol and then finally in the kidney at
position 1a to become 1a, 25-dihydroxycholecalciferol [= 1a, 25-(OH)2-D3].
Further generations of Vitamin D analogues have since been developed. The most important of
these are the so-called D hormone 1a, 25-(OH)2-D3 (= calcitriol) and its analogue alfacalcidol (= 1a-OH-D3) which are highly effective drugs for the treatment of renal bone disease.
Further successful indications for active Vitamin D analogues include hypoparathyroidism and osteomalacia.
With regards osteoporosis, the role of an insufficient Vitamin D
supply or impairment in activation was underestimated for a long time. A breakthrough was achieved with studies showing that the prevalence of mild to moderate vitamin D deficiency
was very high and increasing with age.
Автор: Rizzoli Название: Atlas of Postmenopausal Osteoporosis ISBN: 1858734436 ISBN-13(EAN): 9781858734439 Издательство: Springer Рейтинг: Цена: 10480.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Ren Rizzoli Menopause is the time in a woman's life when reproductive capacity ends. Ovaries decrease their activity and the production of sex hormones ceases. This period may be associated with a large variety of symptoms affecting the cardiovascular and urogenital systems, as well as skin, hair and bone. Bone capital is accumulated by the end of the second decade and remains more or less constant up to the time of menopause. Sex hormone deficiency leads to accelerated bone turnover, a negative balance and microarchitectural deterioration, which compromises bone strength, thereby increasing bone fragility and, thus, fracture risk. By the age of 80, it is estimated that 50% of trab- ular bone will have been lost. Natural menopause occurs between the ages of 45 and 54 years all over the world. This age does not appear to have changed significantly over the centuries. In contrast, since the middle of the 19th century, life expectancy, particularly in women, has increased considerably, with most women living to the age of 80 years or more in many regions of the world. This means that at the age of 50 years, a woman will live for more than 30 years without bone protection by sex hormones. This r- resents more than one-third of a woman's life. At the age of 50 years, the lifetime risk to experience a fracture is about 50% (ie, one out of two women will have a fracture during this period).
Автор: Eastell Название: Practical Guide to Osteoporosis.2002 ISBN: 185317887X ISBN-13(EAN): 9781853178870 Издательство: Taylor&Francis Цена: 13628.00 р. Наличие на складе: Поставка под заказ.
Описание: Beginning with a comprehensive definition of this widespread and debilitating disease, the authors of A Practical Guide to Osteoporosis then go on to describe its diagnosis through various techniques now available to msure bone density, before discussing the various forms of treatment available. The book will prove a valuable reference tool for the specialist as well as a practical guide for the general practitioner dealing with patients presenting with the disease. Further invaluable information is given through the inclusion of an Appendix listing reference ranges for bone mineral densitometry and biochemical markers.
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