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PIPAC: Pressurized IntraPeritoneal Aerosol Chemotherapy – Cancer under Pressure, Marc A. Reymond, Wiebke Solass


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Автор: Marc A. Reymond, Wiebke Solass
Название:  PIPAC: Pressurized IntraPeritoneal Aerosol Chemotherapy – Cancer under Pressure
ISBN: 9783110345940
Издательство: Walter de Gruyter
Классификация:



ISBN-10: 3110345943
Обложка/Формат: Hardback
Страницы: 252
Вес: 0.62 кг.
Дата издания: 15.09.2014
Серия: Medicine
Язык: English
Размер: 244 x 175 x 15
Читательская аудитория: Professional and scholarly
Ключевые слова: Clinical & internal medicine, MEDICAL / Chemotherapy,MEDICAL / Gastroenterology,MEDICAL / Surgery / General
Основная тема: MEDICAL / Chemotherapy,MEDICAL / Surgery / General,MEDICAL / Gastroenterology
Ссылка на Издательство: Link
Поставляется из: Германии
Описание: Peritoneal dissemination is a common route of cancer metastasis. The benefit of administering chemotherapy directly into the peritoneal cavity is supported by preclinical and pharmacokinetic data. In comparison to intravenous (IV) treatment, intraperitoneal (IP) administration results in a several-fold increase in drug concentration within the abdominal cavity. There is now growing evidence from clinical studies showing a survival advantage for IP chemotherapy in various tumor typies, including ovarian, gastric and colorectal cancer.However, while the use of IP chemotherapy is slowly gaining acceptance, it is not universal, largely due to the greater toxicity associated with this approach. Moreover, efficacy of IP chemotherapy is limited by poor distribution within the abdominal cavity and by poor tissue penetration. A new way of IP chemotherapy is the application of cytotoxics in form of a pressurized aerosol into the abdominal of thoracic cavity. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is applied through laparoscopic access using two balloon trocars in an operating room equipped with laminar air-flow. In a first step,a normothermic capnoperitoneum is established with a pressure of 12 mmHg. A cytotoxic solution (about 10% of a normal systemic dose) is nebulized with a micropump into the abdominal cavity, and maintained for 30 min. The aerosol is then removed through a closed suction system. Applying an aerosol in the peritoneal cavity allows a homogeneous distribution of the chemotherapeutic agent within the abdomen. Furthermore, an artificial pressure gradient is generated that overcomes tumoral interstitial fluid pressure, an obstacle in cancer therapy. This results in a higher local drug concentration compared to conventional IP or IV chemotherapy. At the same time the plasma concentration of the chemotherapeutic agent remains low. In first clinical studies with limited number of patients in ovarian, gastric and colorectal cancer, as well as peritoneal mesothelioma, PIPAC has obtained encouraging tumor response rates and survival, with a low-side effects profile. Larger clinical trials are currently ongoing to examine if these data can be reproduced and extrapolated to other situations.


Cancer Chemotherapy in Clinical Practice

Автор: Priestman, Terrence
Название: Cancer Chemotherapy in Clinical Practice
ISBN: 0857297260 ISBN-13(EAN): 9780857297266
Издательство: Springer
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Цена: 8384.00 р.
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Описание: A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience.

Antimicrobial Chemotherapy 5/e P. 2007

Автор: Greenwood
Название: Antimicrobial Chemotherapy 5/e P. 2007
ISBN: 0198570163 ISBN-13(EAN): 9780198570165
Издательство: Oxford Academ
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Цена: 6328.00 р.
Наличие на складе: Поставка под заказ.

Описание: Aims to encourage good prescribing habits in doctors throughout the world, by describing the basic properties of antibiotics and other antimicrobial agents, and discussing the principles underlying the rational use of antimicrobial agents in the management of infection.

Induction chemotherapy: integrated treatment programs for locally advanced cancers

Автор: Aigner, Karl Reinhard; Stephens, Frederick O. (Eds
Название: Induction chemotherapy: integrated treatment programs for locally advanced cancers
ISBN: 3642181724 ISBN-13(EAN): 9783642181726
Издательство: Springer
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Цена: 16070.00 р.
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Описание: Induction chemotherapy, as part of an integrated plan of management for locally advanced cancers, is being practiced throughout the world, but frequently teams are unaware of the work being undertaken in other institutions. This book aims to present the full range of management techniques used in induction chemotherapy within one accessible volume. It provides up-to-date information on pioneering and cutting edge practices and documents the advantages of integrated treatment schedules. Patient selection is discussed, and each of the cancer types for which induction therapy has proved important is considered in detail. All who are responsible for the treatment of patients with locally advanced cancers will find this book to be an invaluable source of information. It will be particularly interesting for specialist oncologists aiming to set up fully comprehensive cancer centers and for health administrators wishing to learn about the benefits of establishing such centers in strategic locations.

Antimicrobial Chemotherapy

Автор: Finch, Roger; Davey, Peter; Wilcox, Mark H.; Irvin
Название: Antimicrobial Chemotherapy
ISBN: 0199697655 ISBN-13(EAN): 9780199697656
Издательство: Oxford Academ
Цена: 6334.00 р.
Наличие на складе: Поставка под заказ.

Описание: Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the ne


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