Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.
Автор: Noebels, Jeffrey; Avoli, Massimo; Rogawski, Michae Название: Jasper`s Basic Mechanisms of the Epilepsies ISBN: 0199746540 ISBN-13(EAN): 9780199746545 Издательство: Oxford Academ Рейтинг: Цена: 25344.00 р. Наличие на складе: Поставка под заказ.
Описание: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment. The book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions.
Автор: Hartmut Geiger (Editor), Jasper Heinrich (Editor), Название: Stem Cell Aging: Mechanisms, Consequences, Rejuvenation ISBN: 3709112311 ISBN-13(EAN): 9783709112311 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.
Автор: Walsh Название: Antibiotics: Challenges, Mechanisms, Opportunities ISBN: 1555819303 ISBN-13(EAN): 9781555819309 Издательство: Wiley Рейтинг: Цена: 16466.00 р. Наличие на складе: Поставка под заказ.
Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
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