Membrane Defenses Against Attack by Complement and Perforins, Charles J. Parker

Автор: Robert B. Sim
Название: Activators and Inhibitors of Complement
ISBN: 9401052247 ISBN-13(EAN): 9789401052245
Издательство: Springer
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Автор: K. Rother; Gerd O. Till; Gertrud M. H?nsch
Название: The Complement System
ISBN: 3642637116 ISBN-13(EAN): 9783642637117
Издательство: Springer
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Описание: The aim of the former editions remains unchanged in the present updated version, namely to put forward a general and comprehensive review on complement. The editors are grateful that the invited authors, all of them leading scientists in their field, helped again to make The Complement System a true mirror of the state of the art.

Автор: Toby K. Eisenstein; Paul Actor; Herman Friedman
Название: Host Defenses to Intracellular Pathogens
ISBN: 1468444832 ISBN-13(EAN): 9781468444834
Издательство: Springer
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Описание: The subject matter of this volume was the basis for a confer- ence held in Philadelphia in June, 1981, and is an important one in the contemporary area of how the host interacts with micro- organisms.

Автор: U.H. Koszinowski; H. Hengel
Название: Viral Proteins Counteracting Host Defenses
ISBN: 3642639747 ISBN-13(EAN): 9783642639746
Издательство: Springer
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Описание: Since the first observations of viral interference with antigen presentation in the MHC class-I pathway, the field has advanced to a detailed analysis.

Автор: John D. Lambris
Название: Current Topics in Complement
ISBN: 1461498015 ISBN-13(EAN): 9781461498018
Издательство: Springer
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Описание: Complement has long been regarded as a pivotal effector arm of the innate im-mune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspec-tive. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory cir-cuits. In this respect, scientists from around the world convened at the Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 5–10, 2005), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the "novel" functions of complement, pathophysiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.