Nucleic Acids and Molecular Biology, Fritz Eckstein; David M. J. Lilley

Автор: David P. Clark
Название: Molecular Biology, 2nd Edition
ISBN: 0123785944 ISBN-13(EAN): 9780123785947
Издательство: Elsevier Science
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Цена: 8104.00 р.
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Описание: The last quarter of the 20th century saw major scientific revolutions in genetics and computer technology. This title reflects massive surge in our understanding of the molecular foundations of genetics. It introduces basic concepts followed by more specific applications as the text evolves.

Автор: Jurga
Название: Modified Nucleic Acids in Biology and Medicine
ISBN: 3319341731 ISBN-13(EAN): 9783319341736
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

Автор: Volker A. Erdmann; Wojciech T. Markiewicz; Jan Bar
Название: Chemical Biology of Nucleic Acids
ISBN: 3642544517 ISBN-13(EAN): 9783642544514
Издательство: Springer
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Цена: 30745.00 р.
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Описание: This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Автор: Volker A. Erdmann; Jan Barciszewski
Название: From Nucleic Acids Sequences to Molecular Medicine
ISBN: 364243083X ISBN-13(EAN): 9783642430831
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Written by leading experts in the field , this book covers hot topics such as small interference RNAs for gene silencing in molecular biology and medicine. Includes numerous illustrations.