Protein Complexes that Modify Chromatin, Jerry L. Workman

Автор: Andrew Emili; Jack Greenblatt; Shoshana Wodak
Название: Systems Analysis of Chromatin-Related Protein Complexes in Cancer
ISBN: 1461479304 ISBN-13(EAN): 9781461479307
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book identifies RNA molecules associated with various chromatin-modifying machines. It explores the biological significance of chromatin machines in cancer (and the development and differentiation of stem cells).

Автор: Gondor, Anita
Название: Chromatin Regulation and Dynamics
ISBN: 0128033959 ISBN-13(EAN): 9780128033951
Издательство: Elsevier Science
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Цена: 17517.00 р.
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Описание: "

Chromatin Regulation and Dynamics" integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases.

Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, "Chromatin Regulation and Dynamics," part of the "Translational Epigenetics" series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation.
Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspectivePromotes crosstalk between basic sciences and their applications in medicineProvides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principlesIntegrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Название: Fundamentals of Chromatin
ISBN: 1461486238 ISBN-13(EAN): 9781461486237
Издательство: Springer
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Цена: 28734.00 р.
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Описание: This book focuses on fundamental properties of chromatin that include structure, composition, modifications and functions in nuclear processes such as transcription, and DNA replication and repair.

Автор: Binda, Olivier
Название: Chromatin Signaling and Diseases
ISBN: 0128023899 ISBN-13(EAN): 9780128023891
Издательство: Elsevier Science
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Цена: 17517.00 р.
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Описание: "

Chromatin Signaling" "and Diseases" covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling.

After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling.

Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in "Chromatin Signaling and Diseases." Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.
Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with agingEducates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathologyExplores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signalingHelps researchers learn about the quickly expanding field of chromatin signaling