Genes, Development and Cancer, Howard D. Lipshitz

Автор: Pelengaris
Название: The Molecular Biology of Cancer, 2nd Edition
ISBN: 1118008812 ISBN-13(EAN): 9781118008812
Издательство: Wiley
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Цена: 10306.00 р. 14723.00 -30%
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Описание: The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment.

Автор: Walter Doerfler; Petra B?hm
Название: DNA Methylation: Development, Genetic Disease and Cancer
ISBN: 3642068308 ISBN-13(EAN): 9783642068300
Издательство: Springer
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Цена: 26120.00 р.
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Описание: It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type.

Автор: Singh Shree Ram
Название: MicroRNA in Development and in the Progression of Cancer
ISBN: 1489980644 ISBN-13(EAN): 9781489980649
Издательство: Springer
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Цена: 23757.00 р.
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Описание: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-? and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

Автор: Slack Frank J
Название: Micrornas In Development And Cancer
ISBN: 1848163665 ISBN-13(EAN): 9781848163669
Издательство: World Scientific Publishing
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Цена: 15048.00 р.
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Описание: MicroRNAs have emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. This book discusses how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease.