Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.
Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.
contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability
documents cutting edge methods
Автор: Craig Nancy Название: Molecular Biology Principles of Genome Function ISBN: 0199658579 ISBN-13(EAN): 9780199658572 Издательство: Oxford Academ Рейтинг: Цена: 9186.00 р. Наличие на складе: Поставка под заказ.
Описание: A fresh, distinctive approach to the teaching of molecular biology. With its focus on key principles, its emphasis on the commonalities that exist between the three kingdoms of life, and its integrated coverage of experimental methods and approaches, Molecular Biology is the perfect companion to any molecular biology course.
Автор: Dennis Название: The Human Genome.2001 ISBN: 0333971434 ISBN-13(EAN): 9780333971437 Издательство: Palgrave Рейтинг: Цена: 3538.00 р. Наличие на складе: Нет в наличии.
Описание: The sequencing of the human genome has been hailed as the most ground breaking scientific event of the new century. It offers the exciting prospect of fresh insights into our collective history, our shared identity and our individuality, and opens up important possibilities for the identification, treatment and prevention of disease. Not since Crick and Watson's seminal paper on the structure of DNA has a scientific publication been greeted with so much public expectation for a new understanding of the basis of life itself. In this illustrated account, written and compiled by Carina Dennis and Richard Gallagher of "Nature", thenome project is made accessible for a general readership. It offers an introduction to the basic biology and techniques, a guide to the main players and events in the history of genetic science, and a range of viewpoints on its impact and reception around the world, in addition to the full text of the research paper itself.
Автор: Kovalchuk, Igor Название: Genome Stability ISBN: 0128033096 ISBN-13(EAN): 9780128033098 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments.
Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.
Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects
Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability
Contains applications of genome instability and its effect on human diseases
Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments
Автор: Nasheuer Название: Genome Stability and Human Diseases ISBN: 9048134706 ISBN-13(EAN): 9789048134700 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive overview discusses cancer cell biology in relation to Genome stability and Cell cycle regulation. Chapters are devoted to genome stability and anti-cancer drug targets, chromatin factors, DNA repair, apoptosis and other key areas of research.
Автор: Dirk-Henner Lankenau Название: Genome Integrity ISBN: 3642072267 ISBN-13(EAN): 9783642072260 Издательство: Springer Рейтинг: Цена: 52967.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is the first book to give a full overview on genome integrity in different species. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. Written by an international panel of experts, the book addresses the connection between genome integrity and human disease.
Автор: Nasheuer Название: Genome Stability and Human Diseases ISBN: 9400731256 ISBN-13(EAN): 9789400731257 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive overview discusses cancer cell biology in relation to Genome stability and Cell cycle regulation. Chapters are devoted to genome stability and anti-cancer drug targets, chromatin factors, DNA repair, apoptosis and other key areas of research.
Автор: Toni Cathomen; Matthew Hirsch; Matthew Porteus Название: Genome Editing ISBN: 1493935070 ISBN-13(EAN): 9781493935079 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "American Society of Gene & Cell Therapy"--Cover.
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