Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, Evandro Fei Fang; Tzi Bun Ng

Автор: Lasek
Название: Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology
ISBN: 3319469053 ISBN-13(EAN): 9783319469058
Издательство: Springer
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Цена: 8489.00 р.
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Описание: This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

Автор: Moses Lee; D.P. Arya; T. Brown; M. Daneshtalab; J.
Название: Heterocyclic Antitumor Antibiotics
ISBN: 3642068146 ISBN-13(EAN): 9783642068140
Издательство: Springer
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Описание:

T. Brown, H. Holt Jr., M. Lee: Synthesis of Biologically Active Heterocyclic Stilbene and Chalcone Analogs of Combretastatin.-