Автор: Montellano Paul R.Ortiz de Название: Cytochrome P450 ISBN: 3319121073 ISBN-13(EAN): 9783319121079 Издательство: Springer Рейтинг: Цена: 53106.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.
Автор: Phillips Ian R. Название: Cytochrome P450 Protocols ISBN: 1588294412 ISBN-13(EAN): 9781588294418 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For this second edition of their much praised Cytochrome P450, the editors have collected accounts of the essential core techniques that use the latest methodologies for the investigation of P450s. Highlights include protocols for spectral analysis and purification of P450s, enzymatic assays of P450s and flavin-containing monooxygenases (FMOs), expression of P450s and FMOs in heterologous systems, and the production and use of antipeptide antibodies. Additional chapters contain readily reproducible techniques for the transfection of hepatocytes for gene regulation studies, P450 reporter gene assays, in situ hybridization, and analysis of genetic polymorphisms. Although the emphasis is on P450s of mammalian origin, many of the readily reproducible methods described are suitable for P450s from any source.
Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, the latest volume in the Advances in Pharmacology series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer.
Автор: Aparajita Dey Название: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism ISBN: 9400758804 ISBN-13(EAN): 9789400758803 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book examines clinical aspects of cytochrome P450 2E1(CYP2E1), covering clinical disorders associated with changes in the regulation of CYP2E1 and consequent abnormalities including alcoholic liver disease, hepatitis C, inhibition of bone repair and more.
Автор: Salgueiro Название: Multiheme Cytochromes ISBN: 3642449603 ISBN-13(EAN): 9783642449604 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This brief introduces the structural and functional characterization of this important group of proteins. The content of each chapter is aimed at the non-specialist so that key concepts, methodologies and applications can be presented in a 'snapshot' style volume. Multiheme cytochromes are ever more important now that it is possible to obtain genome sequences of microorganisms which have major biotechnological and environmental implications. There is a tremendous profusion of multiheme cytochromes which have great potential as targets for bioremediation and bioenergy applications. This brief gives a glimpse of an intriguing and fast-moving field.
Автор: Geoffrey R. Moore; Graham W. Pettigrew Название: Cytochromes c ISBN: 3642745385 ISBN-13(EAN): 9783642745386 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cytochromes c are haemoproteins which carry out electron transfer in a wide variety of biological systems, necessitating different kinds of cytochrome c to fulfill different biological roles.
Автор: Eric F. Johnson Название: Cytochrome P450, Part C,357 ISBN: 0121822605 ISBN-13(EAN): 9780121822606 Издательство: Elsevier Science Рейтинг: Цена: 26275.00 р. Наличие на складе: Поставка под заказ.
Описание: Covers human genomics and genetics, structure and mechanism, regulation of expression, metabolism, and invertibrate P450s.
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