Richard Bott; Christian Betzel Subtilisin Enzymes 9781461379959

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Автор: Richard Bott; Christian Betzel
Название: Subtilisin Enzymes
ISBN: 9781461379959
Издательство: Springer
Классификация:

Медицинская генетика

Прикладная физика и специальные темы

Биофизика

Ботаника и науки о растениях

Зоология и науки о животных

ISBN-10: 1461379954
Обложка/Формат: Soft cover
Страницы: 288
Вес: 0.54 кг.
Дата издания: 15.10.2013
Серия: Advances in Experimental Medicine and Biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: Xi, 288 p.
Размер: 244 x 170 x 17
Читательская аудитория: Professional & vocational
Основная тема: Human Genetics
Подзаголовок: Practical Protein Engineering
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Subtilisin is the most extensively studied model system for protein engineering. The primary motivating factor for the interest in subtilisin is the commercial utility of this class of proteases. The subtilisin symposium was the first international meeting to bring together a large number of groups that have focused on the subtilisins and the subtilases-the protein superfamily of subtilisin-like enzymes. The results presented at the symposium are in this way a unique compendium of a broad spectrum of work largely focused on harnessing the potential of site-directed mutagenesis to understand and deliberately alter the function of these enzymes toward a desired end. This sort of protein engineering has been extremely successful in subtilisin, with many such engineered enzymes now widely used in commer cial enterprises. In this regard the experience derived from subtilisin does represent practical protein engineering. It is becoming clear that subtilisin represents a larger class of enzymes, the subtilases, that include many of the human pro hormone-converting enzymes. As international collabo rative efforts to sequence entire genomes continue, we can reasonably expect that additional members of the subtilase class will be encountered. Whenever interest in a member of this class of enzyme arises, the work on subtilisin will serve as a guide to the analysis for what in bacillus, fungi, and industry is an everyday workhorse enzyme.
Дополнительное описание: I. Structural Studies of Subtilisin Enzymes Alone and in Complex with Inhibitors.- 1. The Complex between Mesentericopeptidase and Eglin-C.- 2. Crystallographic Study of Eglin-C Binding to Thermitase.- 3. Design of Specific Peptide Structures and Subtilis

Subtilisin Enzymes, Richard Bott; Christian Betzel