Gap Junctions in the Nervous System, David C. Spray; Rolf Dermietzel
Автор: Lorenza Gonz?lez-Mariscal Название: Tight Junctions ISBN: 1441941150 ISBN-13(EAN): 9781441941152 Издательство: Springer Цена: 27951.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ight junctions (TJs) are cell-ceil adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and the lateral Tmembrane. These junctions are crucial for the establishment of separate compartments in multicellular organisms and for the exchange of substances between the internal milieu and the external environment. The perception of TJs has changed over the years. From being regarded as static paracellular seals, they have come to be perceived as dynamic structures that adjust their morphol- ogy and function in response to physiological, pharmacological and pathologi- cal challenges. The roles that TJs play in epithelial and endothelial cells has also widened, and nowadays this structure is regarded not only as a fence that limits within the membrane, the movement of proteins and lipids between the apical and basolateral membranes, or as a gate that regulates in a size and charge selec- tive manner the transit of ion and molecules through the paracellular pathway, but also as a structure integrated by molecules that participate in the control of cell proliferation. These observations highlight the importance of understand- ing TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. This broader perception of TJs is reflected in all the chapters of the book and has been attained thanks to the identification in recent years of a wide array of proteins that constitute TJs in epithelial and endothelial cells as well as in central nervous system myelin.
Автор: Walter Hendelman, Peter Humphreys and Christopher Название: The Integrated Nervous System ISBN: 1420045970 ISBN-13(EAN): 9781420045970 Издательство: Taylor&Francis Рейтинг: Цена: 10411.00 р. Наличие на складе: Поставка под заказ.
Описание: To demonstrate the connection between academic neuroanatomy and the practice of clinical neurology, this innovative textbook presents carefully chosen clinical cases that illustrate how the nervous system is constructed and how it functions under normal circumstances. Providing the foundation needed to encounter neurological diseases, it teaches students and residents how to integrate a patient?s clinical history and examination with neuroanatomy. In addition to color illustrations throughout, the book adds an invaluable DVD for further exploration and access to a state-of-the-art website with additional materials that are updated periodically.
Автор: Fred H. Gage; Anders Bj?rklund; Alain Prochiantz Название: Stem Cells in the Nervous System: Functional and Clinical Implications ISBN: 3642623395 ISBN-13(EAN): 9783642623394 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: After 40 years of research, scientists have confirmed that persistent neurogenesis occurs in the adult mammalian brain. The obvious next question is: "Are the newly generated neurons functional?" If so, "What are the functions of these new neurons?" This volume intends to clarify both questions by providing the latest data available.
Название: Tight Junctions Second Edition ISBN: 0849323835 ISBN-13(EAN): 9780849323836 Издательство: Taylor&Francis Рейтинг: Цена: 30624.00 р. Наличие на складе: Поставка под заказ.
Описание: As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cl and molecular biology, genetics and physiology. The field has advanced so fast and so far that it influences many areas of biology and now has practical implications for pharmacology of drug delivery and understanding a wide range of diseases altering epithelial permeability.
Автор: Martin Tracey A Название: Tight Junctions in Cancer Metastasis ISBN: 9400760272 ISBN-13(EAN): 9789400760271 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book summarizes current knowledge of tight junctions and their role in cancer and cancer metastasis. Coverage includes fundamental changes in tight junctions in the process of cancer development and the importance of cellular structure in drug therapy.
Описание: Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. * How do cadherins and catenins interact to assemble AJs and mediate adhesion? * How do AJs interface with other cellular machinery to couple adhesion with the whole cell? * How do AJs affect cell behaviour and multicellular development?
Автор: Dr. Mahboob Ul Hussain Название: Connexins: The Gap Junction Proteins ISBN: 813221918X ISBN-13(EAN): 9788132219187 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins. The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental aspects of connexin family. This book will be useful to broad audience that includes under-and post-graduate students, research scholars, clinicians, etc. The reference section at the end of the book will be helpful for those who seek to know deeper details about this family of proteins.
Автор: Michael Rose Название: Channelopathies of the Nervous System ISBN: 0750645075 ISBN-13(EAN): 9780750645072 Издательство: Elsevier Science Рейтинг: Цена: 14589.00 р. Наличие на складе: Поставка под заказ.
Описание: Channelopathies of the Nervous System is the first definitive and comprehensive work on the rapidly expanding field of ion channel disorders affecting the central and peripheral nervous systems. This cutting edge publication first gives the reader a concise state of the art overview of the important role of ion channels in normal neurological function. It then focuses on the clinical manifestations of ion channel dysfunction. Beginning with basic physiology, molecular biology, genetics and pharmacology of the ion channels, it next considers methods of assessing ion channel function in vitro and in clinical practice. It elucidates the role of altered ion channel gene expression in normal development, and in response to injury or demyelination. It reviews the neurological diseases caused by both hereditary or acquired channelopathies.
Автор: Brodal Название: The Central Nervous System.2003 ISBN: 0195165608 ISBN-13(EAN): 9780195165609 Издательство: Oxford Academ Цена: 8712.00 р. Наличие на складе: Поставка под заказ.
Описание: A major goal of this well-established textbook is to provide knowledge and understanding of neuroscience as a basis for clinical thinking. The strong emphasis on linking basic sciences with their clinical application has implications for the choices of which topics to treat in depth and which to treat more summarily - making this different from most other neuroscience textbooks. For example, topics of great practical importance like the cranial nerves, the autonomic nervous system, and pain are treated in depth.
Автор: Stacia B. Moffet Название: Nervous System Regeneration in the Invertebrates ISBN: 3642798411 ISBN-13(EAN): 9783642798412 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The nervous system is usually involved in repair of other body systems and often may itself require repair.
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