Cortico-Hippocampal Interplay and the Representation of Contexts in the Brain, Robert Miller
Автор: Dori Derdikman; James J. Knierim Название: Space,Time and Memory in the Hippocampal Formation ISBN: 3709112915 ISBN-13(EAN): 9783709112915 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides comprehensive, up-to-date information about the hippocampal formation and especially the neural basis of episodic memory, spatial location (the formation of the cognitive map) and temporal representation.
Автор: Kuei-Yuan Tseng Название: Cortico-Subcortical Dynamics in Parkinson`s Disease ISBN: 1617378836 ISBN-13(EAN): 9781617378836 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book assembles all that is currently known about the pathophysiological changes underlying Parkinson`s Disease (PD). It integrates key aspects of current PD knowledge and research, and provides critical reviews about mechanisms of neurodegeneration.
Автор: Minoru Kimura; Ann M. Graybiel Название: Functions of the Cortico-Basal Ganglia Loop ISBN: 4431685499 ISBN-13(EAN): 9784431685494 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this volume, which is based on the proceedings of the international symposium "Functional Linkages Between the Cerebral Cortex and Basal Ganglia in the Control of Voluntary Movement", held December 1993 in Osaka, Japan, the world's leading neuroscientists present the most up-to-date findings of current research on cortico-basal ganglia relations. Topics addressed in this book include the structure and function of basal ganglia cells and systems, the organization of thalamo-cortical systems, the frontal cortex, and clinical applications of ongoing studies. Of particular interest is the analysis of models of motor learning and functional schemes of cortico-basal ganglia and striatal circuitry. The valuable new insights this interdisciplinary work provides will benefit researchers and students in fields such as neurobiology, behavioral neurophysiology, neurochemistry, and neuropharmacology.
Описание: This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
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