Pathologies of Calcium Channels, Norbert Weiss; Alexandra Koschak

Автор: Jana
Название: Inflammation: the Common Link in Brain Pathologies
ISBN: 9811017107 ISBN-13(EAN): 9789811017100
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This unifying theme of this book-with sections on mechanisms of defense and neuropathogenesis, neurological diseases, infections of the nervous system, neuropharmacology, and novel therapies-is interactions of the immune and nervous systems. It also discusses the role of inflammation as a key mediator of different brain disorders. There have been significant scientific advances in the multidisciplinary field of neuroimmunology / neuroinflammation in the past decade, and this book, edited under the guidance of Professor P. N. Tandon, fosters communication between those who share an interest in this exciting area, including neuroscientists, immunologists, cell biologists, clinicians and neuropharmacologists.

Автор: Peter C. Ruben
Название: Voltage Gated Sodium Channels
ISBN: 3642415873 ISBN-13(EAN): 9783642415876
Издательство: Springer
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Цена: 46118.00 р.
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Описание: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Автор: Bernd Nilius; Veit Flockerzi
Название: Mammalian Transient Receptor Potential (TRP) Cation Channels
ISBN: 3319051601 ISBN-13(EAN): 9783319051604
Издательство: Springer
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Цена: 41925.00 р.
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Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.

Автор: Gerald Werner Zamponi
Название: Voltage-Gated Calcium Channels
ISBN: 1441934111 ISBN-13(EAN): 9781441934116
Издательство: Springer
Цена: 28732.00 р.
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Описание: oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar- macological targets in the treatment of a variety of disorders, such as epi- lepsy, hypertension, and pain. Voltage-gated calcium channels have there- fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl- edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac- tivity, the book delves into a provocative overview of the history of the cal- cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat- ing, permeation, modulation and interactions with members of the exo- totic machinery--contributed by both established leaders and rising stars in the field.

Автор: Rodolfo Madrid; Juan Bacigalupo
Название: TRP Channels in Sensory Transduction
ISBN: 331918704X ISBN-13(EAN): 9783319187044
Издательство: Springer
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Цена: 19564.00 р.
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Описание: TRP channels play a key role in sensory physiology and have been the focus of intensive investigation in recent years. The proposed book will be a comprehensive, detailed overview of the ways in which TRP channels are involved in a wide variety of sensory modalities. Authors will explore the involvement of TRP channels in photo transduction (sight), chemotransduction (taste and odor), mechanotransduction (touch and hearing), thermo transduction (the sensation of temperature) and pain perception. Furthermore, the book will include some grounding chapters such as one on the history of TRP channel research, one on the biophysical characteristics of the proteins and one on trafficking and post-translational regulation.

Автор: Bernd Nilius; Veit Flockerzi
Название: Mammalian Transient Receptor Potential (TRP) Cation Channels
ISBN: 364254214X ISBN-13(EAN): 9783642542145
Издательство: Springer
Рейтинг:
Цена: 53106.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field will describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.