Ismail Adeniran Modelling the Short QT Syndrome Gene Mutations 9783319071992

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Автор: Ismail Adeniran
Название: Modelling the Short QT Syndrome Gene Mutations
ISBN: 9783319071992
Издательство: Springer
Классификация:

Медицинская генетика

Сердечно-сосудистая медицина

Науки о жизни (медико-биологические): общие вопросы

Клеточная биология (цитология)

ISBN-10: 3319071998
Обложка/Формат: Hardcover
Страницы: 217
Вес: 0.52 кг.
Дата издания: 01.07.2014
Серия: Springer Theses
Язык: English
Издание: 2014 ed.
Иллюстрации: 38 illustrations, color; 64 illustrations, black and white; xvii, 217 p. 102 illus., 38 illus. in color.
Размер: 234 x 156 x 14
Читательская аудитория: Professional & vocational
Основная тема: Systems Biology
Подзаголовок: And Their Role in Cardiac Arrhythmogenesis
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases. The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as “outstanding.”
Дополнительное описание: Ion Channels and the Action Potential.- Potassium Channels Implicated in the Short QT Syndrome.- The Short QT Syndrome.- Model Development.- Methods, Experimental Protocols and Mathematical Preliminaries.- Increased Vulnerability of the Human Ventricle to

Modelling the Short QT Syndrome Gene Mutations, Ismail Adeniran