Ryan J. Sullivan BRAF Targets in Melanoma 9781493921423

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Автор: Ryan J. Sullivan
Название: BRAF Targets in Melanoma
ISBN: 9781493921423
Издательство: Springer
Классификация:

Медицинские исследования

Онкология

Дерматология

ISBN-10: 1493921428
Обложка/Формат: Hardcover
Страницы: 204
Вес: 0.49 кг.
Дата издания: 25.11.2014
Серия: Cancer Drug Discovery and Development
Язык: English
Издание: 2015 ed.
Иллюстрации: 5 tables, black and white; 21 illustrations, color; 5 illustrations, black and white; viii, 204 p. 26 illus., 21 illus. in color.
Размер: 234 x 156 x 13
Читательская аудитория: Professional & vocational
Основная тема: Cancer Research
Подзаголовок: Biological Mechanisms, Resistance, and Drug Discovery
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
Дополнительное описание: Melanoma: Historical Context.- Melanoma Pathogenesis.- Molecular Diagnostics and Tumor Mutational Analysis.- Clinical Utility of BRAF-targeted therapy in Melanoma.- The Ethics of Randomized Trials in Oncology.- Parallel and Serial Blockade Strategies in B

BRAF Targets in Melanoma, Ryan J. Sullivan