Multifaceted Roles of Crystallography in Modern Drug Discovery, Giovanna Scapin; Disha Patel; Eddy Arnold

Автор: Giovanna Scapin; Disha Patel; Eddy Arnold
Название: Multifaceted Roles of Crystallography in Modern Drug Discovery
ISBN: 9401797188 ISBN-13(EAN): 9789401797184
Издательство: Springer
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Описание: The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery.

Автор: Ladd Mark F.C., Palmer Rex A.
Название: Structure Determination by X-Ray Crystallography
ISBN: 0306474530 ISBN-13(EAN): 9780306474538
Издательство: Springer
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Описание: There have been many advances in x-ray crystallography since the production of the third edition of this book, and the authors have endeavoured to introduce a number of them into this new edition. The overall plan of the book has been maintained because we believe that it has been well received in the academic community, but substantial revisions have been carried out and new material and chapters added. In particular, we have extended the discussion of the theory of x-ray diffraction and added new chapters on structure determination from powder data, on macromolecular crystallography, and on computational procedures in x-ray crystallography. We consider that x-ray crystallography is a universal tool for studying molecular structure, a view upheld by the pioneers in the subject, notably W.H. & W.L. Bragg, J. D. Bernal, Dorothy Hodgkin (nГ©e Crowfoot), Kathleen Lonsdale (nГ©e Yardley), and Linus Pauling, so that the broadening of the scope of the text in this way is fully justified. We have maintained the practice of devising problems to illustrate the work of each chapter, and have provided detailed, tutorial solutions. The appendices contain mostly mathematical procedures related to the material of the main text.This edition is accompanied by a suite of computer programs on a compact disc. The programs enable the reader to participate fully in many of the aspects of x-ray crystallography discussed in the book. In particular, the program system XRAY* is interactive, and enables the reader to follow through, at the monitor screen, the computational techniques involved in single-crystal structure determination, albeit in two dimensions. Several sets of x-ray data are provided for practice with this system.

Автор: Giacovazzo, Carmelo; Monaco, Hugo Luis; Artioli, G
Название: Fundamentals of Crystallography
ISBN: 0199573662 ISBN-13(EAN): 9780199573660
Издательство: Oxford Academ
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Описание: Crystallography is a basic tool for scientists in many diverse disciplines. This book offers a clear description of fundamentals and of modern applications. It will support curricula in crystallography at undergraduate level, contains material for advanced and specialized courses, and offers tools and ideas for courses in other disciplines.

Автор: Thomas G. Davies; Marko Hyv?nen
Название: Fragment-Based Drug Discovery and X-Ray Crystallography
ISBN: 3642446353 ISBN-13(EAN): 9783642446351
Издательство: Springer
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Описание:

Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson

Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle

Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard

Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. Stamford

Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter Huber

Targeting Protein-Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko Hyv nen

Fragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy Arnold

Fragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan

Автор: Jeffrey, George A. (Department of Crystallography,
Название: An Introduction to Hydrogen Bonding
ISBN: 0195095499 ISBN-13(EAN): 9780195095494
Издательство: Oxford Academ
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Описание: This text seeks to supplement the often brief descriptions of hydrogen bonding found in some undergraduate chemistry and molecular biology textbooks. It discusses current ideas ranging from the very strong to the very weak, with introductions to the experimental and theoretical methods involved.

Автор: Rho Mannque Et Al
Название: Multifaceted Skyrmion, The (Second Edition)
ISBN: 9814704407 ISBN-13(EAN): 9789814704403
Издательство: World Scientific Publishing
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Описание: This book presents, in the form of reviews by world's leading physicists in wide-ranging fields in theoretical physics, the influence and prescience of Skyrme's daring idea of 1960, originally conceived for nuclear physics, that fermions can arise from bosons via topological solitons, pervasively playing a powerful role in wide-ranging areas of physics, from nuclear/astrophysics, to particle physics, to string theory and to condensed matter physics.The skyrmion description, both from gauge theory and from gauge/gravity duality, offers solutions to some long-standing and extremely difficult problems at high baryonic density, inaccessible by QCD proper. It also offers explanations and makes startling predictions for fascinating new phenomena in condensed matter systems. In both cases, what is at the core is the topology although the phenomena are drastically different, even involving different spacetime dimensions.This second edition has been expanded with addition of new reviews and extensively updated to take into account the latest developments in the field.

Автор: A.A. Chernov; E.J. Givargizov; K.S. Bagdasarov; V.
Название: Modern Crystallography III
ISBN: 3642818374 ISBN-13(EAN): 9783642818370
Издательство: Springer
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Описание: Early in this century, the newly discovered x-ray diffraction by crystals made a complete change in crystallography and in the whole science of the atomic structure of matter, thus giving a new impetus to the development of solid-state physics.

Автор: L.A. Shuvalov; L.A. Shuvalov; A.A. Urusovskaya; I.
Название: Modern Crystallography IV
ISBN: 3642818404 ISBN-13(EAN): 9783642818400
Издательство: Springer
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Описание: Modern Crystallography IV is devoted to a systematic and up- to-date description of fundamental physical properties of solid and liquid crystals.

Автор: Boris K. Vainshtein; Vladimir M. Fridkin; Vladimir
Название: Modern Crystallography 2
ISBN: 3642631703 ISBN-13(EAN): 9783642631702
Издательство: Springer
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Описание: The four-volume treatment Modern Crystallography presents an encyclopaedic exposition of problems concerning the structure of crystals, their growth and their properties. Structure of Crystals deals with crystal structures in inorganic and organic compounds, polymers, liquid crystals, biological crystals and macromolecules.

Автор: Boris K. Vainshtein; V.M. Fridkin; V.L. Indenbom
Название: Modern Crystallography II
ISBN: 3642966217 ISBN-13(EAN): 9783642966217
Издательство: Springer
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Описание: Early in this century, the newly discovered x-ray diffraction by crystals made a complete change in crystallography and in the whole science of the atomic structure of matter, thus giving a new impetus to the development of solid-state physics.