Frank Kozielski, FSB Kinesins and Cancer 9789401797313

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Автор: Frank Kozielski, FSB
Название: Kinesins and Cancer
ISBN: 9789401797313
Издательство: Springer
Классификация:

Клеточная биология (цитология)

ISBN-10: 9401797315
Обложка/Формат: Hardcover
Страницы: 271
Вес: 0.61 кг.
Дата издания: 24.03.2015
Язык: English
Издание: 2015 ed.
Иллюстрации: 32 illustrations, color; 18 illustrations, black and white; x, 271 p. 50 illus., 32 illus. in color.
Размер: 234 x 156 x 18
Читательская аудитория: General (us: trade)
Основная тема: Cancer Research
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development. Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future. The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail.
Дополнительное описание: Preface.- The kinesin superfamily.- The discovery and development of Eg5 inhibitors for the clinic.- Mechanism of action of Eg5 inhibitors.- Clinical trials of mitotic kinesin inhibitors.- Kif15; a useful target for anti-cancer therapy?.- Down-regulating

Kinesins and Cancer, Frank Kozielski, FSB