Resistance to Immunotoxins in Cancer Therapy, Rama Shanker Verma; Benjamin Bonavida

Автор: Phuc Van Pham
Название: Breast Cancer Stem Cells & Therapy Resistance
ISBN: 3319220195 ISBN-13(EAN): 9783319220192
Издательство: Springer
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Цена: 9141.00 р.
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Описание: This volume thoroughly examines breast cancer stem cells (BCSCs), from basic definitions to techniques for identifying, isolating, culturing, and targeting BCSCs for therapy;

Название: Resistance to photodynamic therapy in cancer
ISBN: 3319127292 ISBN-13(EAN): 9783319127293
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.