Описание: Children and Youth with Autism Spectrum Disorder (ASD) is a state-of-the-art volume of 15 chapters across four thematic sections that reflect the current convention of viewing autism along a continuum of presenting symptoms.
Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings.
In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders.
Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field.
The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms.
Описание: Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Most scientific training programs provide little or no systematic introduction to the issues, challenges, and obstacles that prevent effective research translation, even though these are the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome. This volume will provide an overview of key issues in translation of research from “bedside to bench to bedside”, not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in the translational research process. It will attempt to offer insight into real-world experience with intellectual property and technology transfer activities that can help move auditory technologies ahead, as scientists and clinicians typically have little or no formal training in these areas. Translational Research in Audiology and the Hearing Sciences will be aimed at graduate students and postdoctoral investigators, as well as professionals and academics. It is intended to function as a high-profile and up-to-date reference work on Translational Research in the auditory sciences, emphasizing research programs in the traditional areas including drugs and devices, as well as less traditional, still emerging, areas such as sensorineural hearing loss, auditory processing disorder, cochlear implants and hearing aids, and tinnitus therapies.
Описание: This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.
Автор: Kristina Hug; G?ran Hermer?n Название: Translational Stem Cell Research ISBN: 1617797243 ISBN-13(EAN): 9781617797248 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: To date, the ethical discussion on human embryonic stem cell research has focused on the moral status of the embryo. This text explores many other ethical, legal and social issues involved in translating stem cell research into medical applications.
Название: Translational neuroscience ISBN: 1489976523 ISBN-13(EAN): 9781489976529 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Chapter 1 - Introduction - Mark H. Tuszynski
Section 1: Molecular Approaches
Chapter 2 - Gene Therapy of CNS Disorders using Recombinant AAV vectors - Giridhar Murlidharan, R. Jude Samulski and Aravind Asokan
Chapter 3 - NGF and BDNF Gene Therapy for Alzheimer's Disease - Alan H. Nagahara and Mark H. Tuszynski
Chapter 4 - GDNF and AADC Gene Therapy for Parkinson's Disease - Krystof Bankiewicz, Waldy San Sebastian, Lluis Samaranch and John Forsayeth
Chapter 5 - GAD Gene Therapy for Parkinson's Disease - Michael G. Kaplitt and Matthew J. During
Chapter 6 - Anti-sense Oligonucleotides
for Amyotrophic Lateral Sclerosis - Wade K. Self and Timothy M. Miller
Chapter 7 - Gene therapy for Inborn Errors of Metabolism: Batten Disease - Dolan Sondhi, Ronald G. Crystal and Stephen M. Kaminsky
Chapter 8 - Gene Therapy for Spinal Cord Injury - Ioana Goganau and Armin Blesch
Chapter 9 - Gene Therapy for Epilepsy - Thomas J. McCown
Chapter 10 - Gene therapy for Pain - Darren Wolfe, David Krisky, James Goss, James Wechuck, Marina Mata and David J. Fink
Section 2: Cellular Approaches
Chapter 11 - Stem Cells for Parkinson's Disease - Andrйs Bratt-Lealand Jeanne F. Loring
quot;serif"">Chapter 12 - Could Stem Cells be used to treat or model Alzheimer's Disease? - Edsel M. Abud and Mathew Blurton-Jones
Chapter 13 - Stem cells for Amyotrophic Late
ral Sclerosis - Anthony Donsante, Lindsey Nicole Urquia and Nicholas M. Boulis
Chapter 14 - Stem cells for Multiple Sclerosis - Pamela Sarkar and Neil Scolding
Chapter 15 - Cell Therapy for Pediatric Disorders of Glia - Joana M. Osorio and Steven A. Goldman
Chapter 16 - Neural Stem Cells for Spinal Cord Injury - Paul Lu, Ruhel Amhad
le="mso-bidi-font-size:12.0pt;font-family: "Times New Roman","serif""> and Mark H. Tuszynski
Chapter 17 - Marrow-derived Mesenchymal Stromal Cells in the Treatment of Stroke - Steve C. Cramer
Chapter 19 - Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer's Disease - Kevin D. Rynearson, Rudolph E. Tanzi and Steven L. Wagner
Chapter 20 - Blocking the Nogo-A signalling pathway to promote regeneration and pla
sticity after spinal cord injury and stroke - tachment: initial; background-size: initial; background-origin: initial; background-clip: initial; background-position: initial; background-repeat: initial;">Anna Magdalena Guzik-Kornacka, Flуra Vajda, Martin E. Schwab
Chapter 21 - Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury - Fengfeng Bei and Zhigang He
Chapter 22 - Voltage-gated ion channels as molecula
r targets for pain - Gerald W. Zamponi, Chongyang Hanand Stephen G. Waxman
Section 4: Activity-Dependent Plasticity and Neurorehabilitation
Chapter 24 - Neural Prostheses for Neurotrauma - Arthur Prochazka
Chapter 25 - Why is Fu
nctional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? - Mary K. Nagai, Cesar Marquez-Chin and Milos R. Popovic
Chapter 26 - Deep Brain Stimulation for Neuropsychiatric Disorders - Ausaf A. Bari, Nicolas Kon Kam King, Nir Lipsman and Andres M. Lozano
Chapter 27 - Novel Interventions for Stroke: Nervous System Cooling - Patrick D. Lyden, Jessica Lamb and Padmesh S. Rajput
This book presents an international research-based framework that has empowered parents of children with autism spectrum disorder (ASD) to become critical decision makers to actively guide their child’s learning and self-advocacy. Parents can use this framework to identify their child’s vision and dreams, and to work with educators and service providers to establish specific learning goals and to implement effective interventions and programs that enable their child to achieve those goals and realise their vision for the future.
The book begins by reviewing available research on evidence-based practice for children with ASD and outlining the Cycle of Learning decision-making framework for parents and professionals. Throughout the remainder of the book, case studies are presented to illustrate the ways in which different parents have successfully utilised this framework to develop effective plans for their child and to advocate for learning and education programs for both their child and other children with ASD in school and community settings. In addition, it highlights concrete examples of how parents have used the framework to empower their children with ASD to develop their self-awareness and self-determination, and to be able to self-advocate as they move through adolescence and into adult life.
Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies.
The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics, and molecular dynamics. It also discusses data integration and mining, immunoinformatics, and neuroinformatics. With broad coverage of both basic scientific and clinical applications, this book is suitable for a wide range of readers who may not be scientists but who are also interested in the practice of personalized medicine.
Introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine
Presents a problem-solving oriented methodology to deal with practical problems in various applications
Covers both basic scientific and clinical applications in order to enhance the collaboration between researchers and clinicians
Brings integrative and multidisciplinary approaches to bridge the gaps among various knowledge domains in the field
Автор: Robbins Название: Translational Neuropsychopharmacology ISBN: 3319339117 ISBN-13(EAN): 9783319339115 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.
Автор: Shashi Bala Singh; Nanduri R. Prabhakar; Srinivas Название: Translational Research in Environmental and Occupational Stress ISBN: 8132219279 ISBN-13(EAN): 9788132219279 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged. This field, which is now widely referred to as Translational Research utilizes basic science findings and translates these findings into innovative concepts for the benefit of mankind. This branch of science has evolved into a multidisciplinary juggernaut encompassing all known fields of science as varied as biomedicine, environment, law, economics, sociology, etc. With the ever increasing interest in this branch and the dreams and aspirations that this field can bring, basic science researchers are now taking a bold step into this new realm, merging different fields of knowledge to come up with novel inventions. This book "Translational research in environmental and occupational stress" provides and insight into the research that led to discoveries, inventions and development of novel technologies which will have a tremendous impact on the future of mankind.
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