Описание: This book is a comprehensive survey of all families of anticancer agents and therapeutic approaches. The book will acts as an indispensable resource for researchers, medicinal chemists and biomedical scientists. The new edition of this book will also have a Companion Website.
Автор: Barnat Edward V., Lu Toh-Ming Название: Pulsed and Pulsed Bias Sputtering / Principles and Applications ISBN: 140207543X ISBN-13(EAN): 9781402075438 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Pulsed and pulsed bias sputter deposition are advanced thin deposition techniques that allow one to produce high quality metal and insulating films. In the pulsed sputtering case, the technique allows one to deposit insulating films while minimizing adverse effects associated with charge accumulation on the target in the reactive deposition mode. In the pulsed bias sputtering case, one can deposit metal films on an insulating substrate while controlling the degree of charging on the substrate. One of the important aspects of these techniques is to be able to control the film properties such as density, orientation, texture, and morphology during deposition. This book provides basic knowledge on the design of the instrumentation for pulsed and pulsed bias sputtering techniques as well as the knowledge for the control of thin film properties using the deposition parameters such as pulsing cycle and duty.The book focuses on the basic principles and experimentation of the pulsed and pulsed bias sputter deposition of thin films. The transient charging characteristics of the target in the DC reactive sputtering of insulator films and of the insulating substrate in the DC sputtering of metal films without the pulsing are discussed in detail. The predictions and experimentation of the discharging (neutralization) strategies using pulsing potentials are presented. Examples are given on the growth of thin films using these strategies and on the relationship between the film properties the pulsing parameters. In addition, the book also presents in a coherent manner the basic physics of DC plasma formation and the utilization of the plasma in the sputtering environment. The book will not only be useful for academic researchers but also for industrial scientists interested in sputter coating of high quality metal and insulating films.
Автор: Kenakin, Terry Название: Pharmacology in Drug Discovery and Development ISBN: 0128037520 ISBN-13(EAN): 9780128037522 Издательство: Elsevier Science Рейтинг: Цена: 11115.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development.
Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization.
This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery.
Автор: Francesco Clementi,Guido Fumagalli Название: General and Molecular Pharmacology: Principles of Drug Action ISBN: 1118768574 ISBN-13(EAN): 9781118768570 Издательство: Wiley Рейтинг: Цена: 20109.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with a particular attention to the mechanisms of drug action the fundamental basis for proper clinical use without neglecting toxicology and pharmacokinetics.
Описание: Presents an introduction to X -ray and neutron reflectivity techniques. This book considers the interplay between the statistics of rough surfaces and interfaces and the scattering of radiation. It describes the method of grazing incidence in small angle X-ray scattering to investigate nanostructures.
Описание: Finally, a book that covers all aspects of the illicit use of cocaine, amphetamines, ecstasy and designer drugs such as GHB, written by two experts in the field. It is a boon for physicians dealing with patients whose drug abuse makes treatment problematic.
Автор: Binghe Wang,Longqin Hu,Teruna J. Siahaan Название: Drug Delivery: Principles and Applications ISBN: 1118833368 ISBN-13(EAN): 9781118833360 Издательство: Wiley Рейтинг: Цена: 20742.00 р. Наличие на складе: Поставка под заказ.
Описание: Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference.
Автор: Mager Название: Systems Pharmacology and Pharmacodynamics ISBN: 3319445324 ISBN-13(EAN): 9783319445328 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
Описание: Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
