Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso Predictive Methods in Percutaneous Absorption 9783662473702

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Автор: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso
Название: Predictive Methods in Percutaneous Absorption
ISBN: 9783662473702
Издательство: Springer
Классификация:

Физиология

Дерматология

Фармакология

Прикладная математика

ISBN-10: 3662473704
Обложка/Формат: Hardcover
Страницы: 199
Вес: 0.49 кг.
Дата издания: 10.07.2015
Язык: English
Издание: 2015 ed.
Иллюстрации: 8 illustrations, color; 8 illustrations, black and white; xv, 199 p. 16 illus., 8 illus. in color.
Размер: 234 x 156 x 14
Читательская аудитория: Professional & vocational
Основная тема: Pharmacology/Toxicology
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
Дополнительное описание: Skin Structure and Physiology.- Methods for the Measurement of Percutaneous Absorption.- Mathematical Treatments and Early Models of Skin Permeability.- “Building error upon error”: The New Breadth of Research in the Field.- Algorithms for Estimating Perm

Predictive Methods in Percutaneous Absorption, Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso