Jiapu Zhang Molecular Structures and Structural Dynamics of Prion Proteins and Prions 9789401773171

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Автор: Jiapu Zhang
Название: Molecular Structures and Structural Dynamics of Prion Proteins and Prions
ISBN: 9789401773171
Издательство: Springer
Классификация:

Медицинское оборудования и методики его эксплуатации

Медицинские исследования

Прикладная физика и специальные темы

Биофизика

Физическая химия

Квантовая и теоретическая химия

Биохимия

Белки

ISBN-10: 9401773173
Обложка/Формат: Hardcover
Страницы: 355
Вес: 0.82 кг.
Дата издания: 25.09.2015
Серия: Focus on Structural Biology
Язык: English
Издание: 1st ed. 2015
Иллюстрации: 35 tables, black and white; 176 illustrations, color; 3 illustrations, black and white; xix, 355 p. 179 illus., 176 illus. in color.
Размер: 242 x 156 x 24
Читательская аудитория: Professional & vocational
Основная тема: Protein Structure
Подзаголовок: Mechanism Underlying the Resistance to Prion Diseases
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This monograph is the first easy-to-read-and-understand book on prion proteins molecular dynamics (MD) simulations and on prions molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the bodys own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in ?-helices but PrPSc are rich in ?-sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the protein structures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to prion diseases; this books MD studies on these species are clearly helpful to understand the mechanism underlying the resistance to prion diseases. PrP(1-120) usually has no clear molecular structures; this book also studies this unstructured region through MD and especially MM techniques from the global optimization point of view. This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.
Дополнительное описание: Basic Knowledge.- The Homology Structure and Dynamics.- The NMR Structure and Dynamics of the Wild-type and Mutants.- Compared with the NMR Structure and Dynamics of Humans and Mice.- Compared with the NMR Structure and Dynamics of Dogs and Horses.- Compa

Molecular Structures and Structural Dynamics of Prion Proteins and Prions, Jiapu Zhang