Описание: Principles of Molecular Diagnostics and Personalized Cancer Medicine" The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care. Improve your understanding of… • The basic mechanisms of carcinogenesis— including material on cell proliferation, signal transduction pathways, cancer stem cells, and the interaction between genetics and environmental factors. • The most current molecular techniques —including polymerase chain reaction (PCR) technique, single nucleotide polymorphisms, cancer cytogenomics and epigenetics, whole-genome assessments, and next- generation sequencing. • Molecular tests —including molecular screening, minimal residual disease detection, circulating tumor cell tests, molecular tumor staging, and molecular cancer prognosis assessment. • Imaging and screening technologies —including molecular imaging, genetic tests, biostatistics, and bioinformatics. • The molecular basis of therapy —including critical molecules as special treatment targets, particularly genes/DNA, RNA, micro RNAs, proteins/antibodies, and nanoparticles. • Molecular diagnostics – including updated molecular diagnostic approaches to common malignancies and role of pathology in targeted cancer management. • Targeted treatment – including personalized medicine and targeted therapy for commonly occurring malignancies— plus insights on new approaches to targeted drug discovery and the future of molecular oncology!
Название: Cancer Genetics and Genomics for Personalized Medicine ISBN: 9814669873 ISBN-13(EAN): 9789814669870 Издательство: Taylor&Francis Рейтинг: Цена: 16537.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine.
The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.
Описание: In the coming decade, the focus of medicine will shift from a disease-oriented approach, where the physician prescribes according to the disease the patient has, to a personalized approach, in which the physician first considers the patient’s individual biochemistry before prescribing a treatment. Personalized medicine has the potential to improve efficacy and safety in virtually all fields of medicine. Unfortunately, few physicians feel confident in their ability to apply the principles of genetics and genomics upon which personalized medicine is based to their practice. This book is intended to help the practicing physician understand and apply the principles of genetic and genomic medicine, regardless of his/her level of background in the field. It provides a thorough foundation/review of classical genetic principles, with an emphasis on how these principles apply to personalized medicine and common complex diseases. In addition, it provides a wide-ranging review of the inroads that personalized medicine has made into several fields, including cancer, psychiatric disorders, cardiovascular disease, substance abuse, Alzheimer disease, respiratory diseases, type 2 diabetes and macular degeneration. Most importantly, this book is intended to enable the practicing physician, physician assistants and their entire healthcare team to anticipate the developments that will emerge in the near future, and stay current with the field as it expands.
Автор: Rossen Donev Название: Personalized medicine,102 ISBN: 012804795X ISBN-13(EAN): 9780128047958 Издательство: Elsevier Science Рейтинг: Цена: 21222.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.
Автор: Debmalya Barh; Dipali Dhawan; Nirmal Kumar Ganguly Название: Omics for Personalized Medicine ISBN: 8132211839 ISBN-13(EAN): 9788132211839 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details how the pharmacogenomics and omics technologies are transforming the medicine and the health care sector for the better. It covers all aspects of pharmacogenomics and its disease-specific applications.
Автор: D. Hunter Best; Jeffrey J. Swensen Название: Molecular Genetics and Personalized Medicine ISBN: 1627039236 ISBN-13(EAN): 9781627039239 Издательство: Springer Рейтинг: Цена: 27951.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews developments in molecular genetics, showing how they have been adopted in clinical practice. The authors simplify complex genetic concepts and focus on patient related issues. The aim is to help shorten the time from lab bench to bedside.
Автор: Jain K.K. Название: Textbook of Personalized Medicine ISBN: 1441907688 ISBN-13(EAN): 9781441907684 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Personalized medicine involves integration and translation of several technologies in clinical care of patients. This book mentions basic technologies for personalized medicine, of which molecular diagnostics has the biggest share. It is suitable for physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge.
1 Lung Cancer Genomics in the Era of Accelerated Targeted Drug Development.-2 Emerging Biomarkers in Personalized Therapy of Lung Cancer.-3 Epithelial mesenchymal transition in aggressive lung cancers.-4 The Role of Cancer Stem Cells in Recurrent and Drug-Resistant Lung Cancer.-5 The microenvironment of lung cancer and therapeutic implications.-6 Epigenetics in Personalized Management of Lung Cancers.-7 Next-Generation Sequencing and Applications to the Diagnosis and Treatment of Lung Cancer.-8 Nanomedicine for Treatment of Lung Cancer.-9 Personalized Therapy of Small Cell Lung Cancer.-10 Personalized Radiation Therapy for Lung Cancer.-11 Current Clinical Management in the era of personalized therapy.-11 Personalized Therapy of Non-Small Cell Lung Cancer.
Название: Towards Personalized Medicine for Cancer ISBN: 1573318159 ISBN-13(EAN): 9781573318150 Издательство: Wiley Рейтинг: Цена: 5346.00 р. Наличие на складе: Поставка под заказ.
Описание: This volume explores cancer as an individualized problem and addresses the impact of recent advances in cancer biology, genetics, tumor profiling, and medical technology in the personalization of cancer predisposition, diagnosis, prognosis, treatment, and therapy development.
Автор: Bodiroga-Vukobrat Название: Personalized Medicine ISBN: 3319393472 ISBN-13(EAN): 9783319393476 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers comprehensive coverage of the various aspects of personalized medicine as an original approach to classifying, understanding, treating and preventing disease based on individual biological differences. In the introductory section, it defines personalized medicine as a way toward new medical practices and addresses the question: What can personalized medicine offer citizens, medical professionals, reimbursement bodies and stakeholders? Subsequent chapters discuss the technological aspects of personalized medicine: data collection, comprehensive integration and handling of data, together with key enabling factors in developing the requisite technological support for personalized medicine. Lastly, the book explores the main issues shaping the implementation and development of personalized medicine – education, stakeholder participation, infrastructure, a new approach to the classification of disease and medical tests, regulatory frameworks, and new reimbursement models – together with ethical, legal and social issues. Ultimately, the book calls for interdisciplinarity and a radical change in the way we approach the health and wellbeing of individuals. Target groups are medical doctors and researchers in the field of biomedicine, as well as experts from the social sciences dealing with legal, economic and social aspects of health system issues in general. Though the book will primarily benefit these groups of professional experts, its content will also appeal to a far wider readership, as it deals with a paradigm shift in one of society’s main pillars – the health system.
Автор: Martial Ruat Название: The Smoothened Receptor in Cancer and Regenerative Medicine ISBN: 3319197541 ISBN-13(EAN): 9783319197548 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.
Автор: Piccart Название: Breast Cancer Management and Molecular Medicine ISBN: 3540282653 ISBN-13(EAN): 9783540282655 Издательство: Springer Рейтинг: Цена: 48913.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides an overview of the techniques, agents and approaches for breast cancer and its treatment. This book presents organ-specific approaches and their impact on the re-classification of breast cancer. It also addresses the integration of biological markers, technologies, diagnostic and therapeutic approaches into clinical trials and practice.
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