Описание: The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development.
Описание: This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).
Автор: Simon Fillatreau; Anne O`Garra Название: Interleukin-10 in Health and Disease ISBN: 3662434911 ISBN-13(EAN): 9783662434918 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.
Автор: Yuzhalin, Arseniy Название: Interleukins in Cancer Biology ISBN: 0128103256 ISBN-13(EAN): 9780128103258 Издательство: Elsevier Science Рейтинг: Цена: 11620.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. .
Описание: This thesis reports on innovations in the design and direct synthesis of graphene-based woven fabric (GWF) and multi-layer graphene/porous carbon woven fabric films (MLG/PC) by means of chemical vapor deposition (CVD), using woven copper mesh and nickel mesh as the template.
Описание: This volume presents recent research on polymer-based smart materials, as well as commercial advances and needs. It focuses on materials development, characterization, processing, manufacturing, analysis, design and applications. Topics include: new materials and characterization; device application; new materials and devices; and E-NSF and new materials.
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