Overflow Metabolism 9780128122082

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Автор: Vazquez, Alexei
Название: Overflow Metabolism
Перевод названия: Алексей Васкес: Метаболизм переполнения
ISBN: 9780128122082
Издательство: Elsevier Science
Классификация:

Биохимия

Молекулярная биология

ISBN-10: 0128122080
Обложка/Формат: Paperback
Страницы: 150
Вес: 0.16 кг.
Дата издания: 27.10.2017
Язык: English
Размер: 230 x 153 x 7
Читательская аудитория: Professional & vocational
Основная тема: Biochemistry
Подзаголовок: From yeast to marathon runners
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание: Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. . This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage.

Overflow Metabolism, Vazquez, Alexei