Описание: The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.
Описание: This book reviews signaling pathways in the regulation of circulatory and respiratory function, integrating biology, chemistry, and physics for a multidisciplinary view of physiological flows. It describes ion and molecular carriers and receptors.
Описание: The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems.
Описание: Providing physicians with vital support in generating computer models and simulations of flows in the cardiovascular and ventilatory systems, this book reviews the systems` anatomy and physiology and shows how to use signals and images as input data.
Описание: Volumes 1 and 2 of Circulatory and Ventilatory Systems focus on cell structure and function (Volume 1) as well as cellular events that allow adaptation to environmental conditions, including cell proliferation and growth, migration, and death (Volume 2). Circadian cycles that drive rhythmic gene transcription are also covered.
Описание: This book provides an overview of the current modeling methods and applications enhancing interventional treatments and computer-aided surgery of human circulatory and pulmonary systems. Descriptions of the techniques behind image acquisition are included.
Описание: Providing physicians with vital support in generating computer models and simulations of flows in the cardiovascular and ventilatory systems, this book reviews the systems` anatomy and physiology and shows how to use signals and images as input data.
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