Genome-Wide Association Studies and Genomic Prediction, Cedric Gondro; Julius van der Werf; Ben Hayes
Автор: Lupski Название: Genomic Disorders. 2006 ISBN: 1588295591 ISBN-13(EAN): 9781588295590 Издательство: Springer Рейтинг: Цена: 10760.00 р. 15372.00-30% Наличие на складе: Есть (1 шт.) Описание: A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.
Автор: Jon F. Wilkins Название: Genomic Imprinting ISBN: 0387775757 ISBN-13(EAN): 9780387775753 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field. Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father.
At a ceremony announcing the completion of the first draft of the human genome in 2000, President Bill Clinton declared, "I believe one of the great truths to emerge from this triumphant expedition inside the human genome is that in genetic terms, all human beings, regardless of race, are more than 99.9 percent the same." Yet despite this declaration of unity, biomedical research has focused increasingly on mapping that.1 percent of difference, particularly as it relates to race.
This trend is exemplified by the drug BiDil. Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was originally touted as a pathbreaking therapy to treat heart failure in black patients and help underserved populations. Upon closer examination, however, Jonathan Kahn reveals a far more complex story. At the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked.
Using BiDil as a central case study, Kahn broadly examines the legal and commercial imperatives driving the expanding role of race in biomedicine, even as scientific advances in genomics could render the issue irrelevant. He surveys the distinct politics informing the use of race in medicine and the very real health disparities caused by racism and social injustice that are now being cast as a mere function of genetic difference. Calling for a more reasoned approach to using race in biomedical research and practice, Kahn asks readers to recognize that, just as genetics is a complex field requiring sensitivity and expertise, so too is race, particularly in the field of biomedicine.
Название: Genome-wide association studies and genomic prediction ISBN: 1627034463 ISBN-13(EAN): 9781627034463 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology(TM) book covers phenotypes of interest as well as design issues for GWAS, methods for storing and handling large datasets, quality control measures, haplotype inference, and imputation and statistical approaches to data analysis.
Автор: Rex A. Dwyer Название: Genomic Perl ISBN: 052180177X ISBN-13(EAN): 9780521801775 Издательство: Cambridge Academ Цена: 7445.00 р. Наличие на складе: Поставка под заказ.
Описание: This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.
Автор: Kumar, Dhavendra; Eng, Charis Название: Genomic Medicine ISBN: 019989602X ISBN-13(EAN): 9780199896028 Издательство: Oxford Academ Рейтинг: Цена: 45276.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition ofGenomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine.
Автор: Jon F. Wilkins Название: Genomic Imprinting ISBN: 1441926585 ISBN-13(EAN): 9781441926586 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field. Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father.
Автор: Igor Jurisica; Dennis A. Wigle; Bill Wong Название: Cancer Informatics in the Post Genomic Era ISBN: 1441943447 ISBN-13(EAN): 9781441943446 Издательство: Springer Рейтинг: Цена: 27951.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science.
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