Mitochondrial Dynamics in Cardiovascular Medicine, Gaetano Santulli

Автор: Orrenius
Название: Mitochondrial Signaling in Health and Disease
ISBN: 1439880026 ISBN-13(EAN): 9781439880029
Издательство: Taylor&Francis
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Описание:

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.

Автор: Volkmar Weissig; Marvin Edeas
Название: Mitochondrial Medicine
ISBN: 1493922874 ISBN-13(EAN): 9781493922871
Издательство: Springer
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Описание: This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction.

Автор: J.J. Lemasters; C.R. Hackenbrock; R.G. Thurman; H.
Название: Integration of Mitochondrial Function
ISBN: 1489925538 ISBN-13(EAN): 9781489925534
Издательство: Springer
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Автор: Keshav K. Singh
Название: Mitochondrial DNA Mutations in Aging, Disease and Cancer
ISBN: 3662125110 ISBN-13(EAN): 9783662125113
Издательство: Springer
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Описание: Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson`s, Alzheimer`s, and Huntington`s diseases.

Автор: Patrick Lestienne
Название: Mitochondrial Diseases
ISBN: 3642641660 ISBN-13(EAN): 9783642641664
Издательство: Springer
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Описание: For those like me who witnessed the beginning of the adventure of human mitochon- drial pathology, one can only be astounded by the extent and unexpectedness of what the field has come to offer. Extent because nobody could have imagined the sheer size of the domain. Unexpectedness because hitherto it was impossible to imagine the clinical polymorphism that this pathology would represent. The starting point was clear. Initially, there was the exceptional, and for a long time unique, observation of euthyroidian hypermetabolism that Luft and colleagues analyzed remarkably in biochemical and clinical terms. Thereafter, there was the support provided by the electron microscopy studies of Afzelius, and the very first visualization of mitochondrial abnormalities. That was way back in 1958. A few years later, progress in the cytology and cytochemistry of skeletal muscle tissue was to provide the means of detecting such abnormalities by examining sections with light microscopy. The colorful term "ragged red fibers", coined by W. K. Engel, became uni- versally accepted, and this typical aspect with Gomori trichrome stain was to throw light on the frequency with which these mitochondrial abnormalities could occur under pathological conditions which, until then, had remained a total mystery regard- ing their mechanism: syndromes such as the ocular myopathies with their descending evolution and the oculocraniosomatic syndromes. We were at the beginning of the 1970s.

Автор: Justin C. St. John
Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells
ISBN: 1627038671 ISBN-13(EAN): 9781627038676
Издательство: Springer
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Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.

Автор: Tatiana K. Rostovtseva
Название: Molecular Basis for Mitochondrial Signaling
ISBN: 3319555375 ISBN-13(EAN): 9783319555379
Издательство: Springer
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Описание: At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established.

Автор: J.J. Lemasters; C.R. Hackenbrock; R.G. Thurman; H.
Название: Integration of Mitochondrial Function
ISBN: 0306429993 ISBN-13(EAN): 9780306429996
Издательство: Springer
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Описание: In aerobic tissues such as heart, brain, kidney, liver and brown fat, mitochon- dria account for more than 20% of cell protein and play an essential role in res- piration, ATP formation, ketogenesis, gluconeogenesis, amino acid metabolism, ureagenesis, thermogenesis and a variety of other metabolic activities. The mecha- nisms by which these activities are integrated and regulated within the overall context of cellular physiology is of much current research interest. In order to bring together scientists examining the various diverse aspects of this overall pro- blem, an International Conference on INTEGRATION OF MITOCHONDRIAL FUNC- TION was held June 4-7, 1987 at the Hanes Art Center on the campus of the Uni- versity of North Carolina at Chapel Hill. The chapters of this volume derive from presentations made at this conference. The focus of INTEGRATION OF MITOCHONDRIAL FUNCTION is on signifi- cant new experimental and theoretical advances concerning integration of mito- chondrial function at the organelle, cell, tissue and whole organism levels of organization.

Автор: Lee-Jun C. Wong
Название: Mitochondrial Disorders
ISBN: 1493959506 ISBN-13(EAN): 9781493959501
Издательство: Springer
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Описание: The variability of clinical symptoms in mitochondrial diseases calls for a systematic presentation of the full range of protocols used in their assessment. This volume provides cutting-edge methods of analysis as well as expert guidance on how to apply them.

Автор: Carlos M. Palmeira; Anabela P. Rolo
Название: Mitochondrial Regulation
ISBN: 1493946129 ISBN-13(EAN): 9781493946129
Издательство: Springer
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Описание:

1. Isolation of Crud Mitochondrial Fraction from Cells

Mariusz R. Wieckowski and Lech Wojtczak

2. Isolation of Mitochondria from Liver and Extraction of Total RNA and Protein - Analyses of MicroRNA and Protein Expressions

Pedro M. Borralho, Clifford J. Steer, and Cecнlia M. P. Rodrigues

3. PCR Based Determination of Mitochondrial DNA Copy Number in Multiple Species

Rooney JP, Ryde IT, Sanders LH, Howlett EH, Colton MD, Germ KE, Mayer GD, Greenamyre JT, and Meyer JN

4. NAD⁺ Content and its Role in Mitochondria

Wei Li and Anthony A. Sauve

5. Measuring PGC-1α and its Acetylation Status in Mouse Primary Myotubes

Ana P. Gomes and David A. Sinclair

6. Measurement of Mitochondrial Oxygen Consumption Rates in Mouse Primary Neurons and Astrocytes

Sofia M. Ribeiro, Alfredo Gimйnez-Cassina, and Nika N. Danial

7. Determination Of Oxidative Phosphorylation Complexes Activities

Joгo S. Teodoro, Carlos M. Palmeira, and Anabela P. Rolo

8. Histoenzymatic Methods for Visualization of the Activity of Individual Mitochondrial Respiratory Chain Complexes in the Muscle Biopsies from Patients with Mitochondrial Defects

Agnieszka Karkucinska-Wieckowska, Maciej Pronicki, and Mariusz R. Wieckowski

9. A Method Aimed at Assessing the Functional Consequences of the Supramolecular Organization of the Respiratory Electron Transfer Chain by Time-resolved Studies

Fabrice Rappaport

10. BN-PAGE-based Approach to Study Thyroid Hormones and Mitochondrial Function

Elena Silvestri, Assunta Lombardi, Federica Cioffi, and Fernando Goglia

11. Detection of UCP1 Protein and Measurements of Dependent GDP-Sensitive Proton Leak in Non-Phosphorylating Thymus Mitochondria

Kieran J. Clarke, Audrey M. Carroll, Gemma O'Brien & Richard K. Porter

12. Exploring Liver Mitochondrial Function By ¹³c-Stable Isotope Breath Tests. Implications In Clinical Biochemistry

Ignazio Grattagliano, Leonilde Bonfrate, Michele Lorusso, Luigi Castorani, Ornella de Bari, and Piero Portincasa

13. Following Mitochondria Dynamism: Confocal Analysis of The Organelle Morphology

F. R. Mariotti, M. Corrado, and S. Campello

Автор: Hong Kyu Lee; Salvatore DiMauro; Masashi Tanaka; Y
Название: Mitochondrial Pathogenesis
ISBN: 1573314919 ISBN-13(EAN): 9781573314916
Издательство: Springer
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Автор: Angelo Azzi; Katarzyna A. Nalecz; Maciej J. Nalecz
Название: Anion Carriers of Mitochondrial Membranes
ISBN: 3642745415 ISBN-13(EAN): 9783642745416
Издательство: Springer
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Описание: All relevant structural and functional aspects of the Anion Carriers of Mitochondrial Membranes as well as isolation procedures, reconstitution experiments and biogenesis of the carriers, kinetics of transport as well as the metabolic regulation mechanisms are treated in this volume.