An Introduction to Dose-Finding Methods in Early Phase Clinical Trials, Takashi Daimon; Akihiro Hirakawa; Shigeyuki Matsui

Автор: Naitee Ting
Название: Dose Finding in Drug Development
ISBN: 144192115X ISBN-13(EAN): 9781441921154
Издательство: Springer
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Описание: If you have ever wondered when visiting the pharmacy how the dosage of your prescription is determined this book will answer your questions. It introduces the drug development process and explains the practical concerns in selecting doses for a new drug.

Автор: Wolfgang von der Linden; Volker Dose; Rainer Fisch
Название: Maximum Entropy and Bayesian Methods Garching, Germany 1998
ISBN: 0792357663 ISBN-13(EAN): 9780792357667
Издательство: Springer
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Описание: Taken from the 1998 MaxEnt conference, this work contains a range of applications of Bayesian probability theory and maximum entropy methods to problems of concern in such fields as physics, image processing, coding theory, machine learning, economics, data analysis and various other problems.

Автор: Wolfgang von der Linden; Volker Dose; Rainer Fisch
Название: Maximum Entropy and Bayesian Methods Garching, Germany 1998
ISBN: 9401059829 ISBN-13(EAN): 9789401059824
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Proceedings of the 18th International Workshop on Maximum Entropy and Bayesian Methods of Statistical Analysis

Автор: K. Dose
Название: The Origin of Life and Evolutionary Biochemistry
ISBN: 1468421174 ISBN-13(EAN): 9781468421170
Издательство: Springer
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Цена: 13974.00 р.
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Описание: The primary metabolism of protobionts was probably based on the electron transfer reactions regulated by catalysts or photo- sensitizing pigments. The action of photoreceptive pigments was inevitable in the case of electron transfer leading to light energy storage in the reaction products. The primitive tetrapyrrolic pig- ments formed abiogenically (porphin, chlorin) as well as their more complicated biogenic analogs (chlorophylls) are capable of photo- sensitizing electron transfer in systems, having various degrees of molecular complexity. The inorganic photosensitizers (titanium dioxide. zinc oxide. etc.). being excited in the near ultraviolet. are able to perform the same reactions as porphyrins--electron transfer from donor to acceptor molecule (including photoreduction of viologens) or water molecule photooxidation (oxygen liberation). coupled with reduction of ferric compounds and quinones. The in- organic photosensitizers are not used in biological evolution; actually the inorganic ions entered into tetrapyrrolic cycle. form- ing effective photocatalysts. Inclusion of pigments into primary membranes led to elaborated coupling between pigments and enzymatic systems. The involvement of the excited pigments into the biocata- lytic electron transfer chain was prerequisite to effective func- tion of photosynthetic organisms. REFERENCES 1. Oparin. A. I., "Origin of Life on Earth," Izd. AN SSSR. Moscow. 1957. 2. Gaffron, H., in: "Horizons in Biochemistry" (Kasha. M -- and Pullmann, B -- eds.), p. 59. Academic Press, New York. 1962. 3. Calvin. M -- "Chemical Evolution," C1arendon Press, Oxford. 1969. 4. Pasynsky. A. G .- and Pav1ovskaya. T. E .- Uspekhii khimii 33, 1198 (1964).

Автор: Berry, Donald A. Berry, Scott M. Carlin, Bradley P
Название: Bayesian adaptive methods for clinical trials
ISBN: 1439825483 ISBN-13(EAN): 9781439825488
Издательство: Taylor&Francis
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Описание: Explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis. This book summarizes the state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative.

Автор: W.J.J. Rey
Название: Introduction to Robust and Quasi-Robust Statistical Methods
ISBN: 3540128662 ISBN-13(EAN): 9783540128663
Издательство: Springer
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