Chromatin Immunoprecipitation, Neus Visa; Antonio Jord?n-Pla

Автор: Srikumar P. Chellappan
Название: Chromatin Protocols
ISBN: 1493956264 ISBN-13(EAN): 9781493956265
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Significant advancements have been made in the study of chromatin structure and function over the past fifty years but none as spectacular as those made in the last decade due to the development of novel techniques and the ability to sequence large stretches of DNA. In Chromatin Protocols, Second Edition, expert researchers delineate these cutting-edge techniques via step-by-step laboratory methods and protocols, which encompass a wide array of topics from the isolation of nucleosomes, assembly of nucleosomes and study of the basic chromatin structure to detailed analysis of histone modifications and chromatin function. Written in the highly successful Methods in Molecular Biology™ series style, chapters include brief introductions to the subjects, lists of the necessary materials and reagents, readily reproducible protocols, and Notes sections which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Chromatin Protocols, Second Edition is a valuable tool for scientists studying various aspects of chromatin function and an ideal guide to aid in the development of new techniques as well as new ideas in the field of chromatin biology.

Автор: Andrew Emili; Jack Greenblatt; Shoshana Wodak
Название: Systems Analysis of Chromatin-Related Protein Complexes in Cancer
ISBN: 1493900897 ISBN-13(EAN): 9781493900893
Издательство: Springer
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Цена: 19589.00 р.
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Описание: This book identifies RNA molecules associated with various chromatin-modifying machines. It explores the biological significance of chromatin machines in cancer (and the development and differentiation of stem cells).

Автор: Remus T. Dame; Charles J. Dorman
Название: Bacterial Chromatin
ISBN: 9400790880 ISBN-13(EAN): 9789400790889
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Bacterial Chromatin provides a complete picture of the essential cellular processes involved like no other existing work. Coverage includes the role of nucleoid-associated proteins, nucleoid imaging techniques and the physics of their structure and segregation.

Автор: Binda, Olivier
Название: Chromatin Signaling and Diseases
ISBN: 0128023899 ISBN-13(EAN): 9780128023891
Издательство: Elsevier Science
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Цена: 17517.00 р.
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Описание: "

Chromatin Signaling" "and Diseases" covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling.

After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling.

Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in "Chromatin Signaling and Diseases." Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.
Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with agingEducates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathologyExplores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signalingHelps researchers learn about the quickly expanding field of chromatin signaling

Автор: Claudio Nicolini
Название: Chromatin Structure and Function
ISBN: 1468409786 ISBN-13(EAN): 9781468409789
Издательство: Springer
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Цена: 16979.00 р.
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Описание: A few chapters, dealing at the level of intact cell and/or in classical genetic terms, with aging, differentiation and neoplastic transformation, have been included to furnish a more comprehensive view of fundamental cell functions directly and indirectly related to the structure and function of the genetic apparatus.

Автор: Donev, Rossen
Название: Chromatin Remodelling and Immunity,106
ISBN: 0128123923 ISBN-13(EAN): 9780128123928
Издательство: Elsevier Science
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Цена: 21222.00 р.
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Описание:

Chromatin Remodelling and Immunity, Volume 106, the latest release in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

Автор: Brehon Laurent
Название: Chromatin Dynamics in Cellular Function
ISBN: 3642070248 ISBN-13(EAN): 9783642070242
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.

Автор: Kirti Prakash
Название: Chromatin Architecture
ISBN: 3319521829 ISBN-13(EAN): 9783319521824
Издательство: Springer
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Цена: 20962.00 р.
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Описание: A Condensed History of Chromatin Research.- Investigating Chromatin Organisation Using Single Molecule Localisation Microscopy.- Structure, Function and Dynamics of Chromatin.- Periodic and Symmetric Organisation of Meiotic Chromosomes.- Conclusions.- Appendices.