Автор: Justin C. St. John Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells ISBN: 1627038671 ISBN-13(EAN): 9781627038676 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.
Автор: Michael Forte; Marco Colombini Название: Molecular Biology of Mitochondrial Transport Systems ISBN: 3642789382 ISBN-13(EAN): 9783642789380 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Research Workshop on Molecular Biology of Mitochondrial Transport Systems, held at Il Ciocco, Italy, September 17 - 21, 1992
Автор: Reeve Название: Mitochondrial Dysfunction in Neurodegenerative Disorders ISBN: 3319286358 ISBN-13(EAN): 9783319286358 Издательство: Springer Рейтинг: Цена: 18866.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson’s disease, Alzheimer’s disease and multiplesclerosis. The reader is guided through the basic functions of mitochondria andthe mechanisms that lead to their dysfunction, and on to the consequences ofthis dysfunction for neuronal function before finishing with the modelling ofthese disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflectadvances in the field and there are many new contributors and topics, includinghow mitochondria are degraded and the interaction of the mitochondria withpathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disordersprovides an accessible, authoritative guide to this important area forneurologists; research and clinical neuroscientists; neuropathologists; andresidents with an interest in clinical research.
Автор: Bingwei Lu Название: Mitochondrial Dynamics and Neurodegeneration ISBN: 9400799470 ISBN-13(EAN): 9789400799479 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written by experts, this book offers comprehensive coverage of the mechanisms of mitochondrial dynamics, from basic research on its molecular basis to medical implications, to the direction of future research. Includes numerous color figures and illustrations.
Автор: Stefan Strack; Yuriy M. Usachev Название: Techniques to Investigate Mitochondrial Function in Neurons ISBN: 1493968882 ISBN-13(EAN): 9781493968886 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Neuromethods Preface... Preface... Table of Contents... Contributing Authors...
1. Three-Dimensional Reconstruction of Neuronal Mitochondria by Electron Tomography Guy Perkins 2. Measuring Mitochondrial Shape with ImageJ Ronald A. Merrill, Kyle H. Flippo, and Stefan Strack 3. Live Imaging Mitochondrial Transport in Neurons Meredith M. Course, Chung-Han Hsieh, Pei-I Tsai, Jennifer A. Codding-Bui, Atossa Shaltouki, and Xinnan Wang 4. Techniques to Investigate Bioenergetics of Mitochondria William I. Sivitz 5. Respirometry in Neurons Liang Zhang and Eugenia Trushina 6. Measuring ATP in Axons with FRET Lauren Y. Shields, Bryce A. Mendelsohn, and Ken Nakamura 7. Characterizing Metabolic States using Fluorescence Lifetime Imaging Microscopy (FLIM) of NAD(P)H Thomas S. Blacker and Michael R. Duchen 8. Techniques for Simultaneous Mitochondrial and Cytosolic Ca2+ Imaging in Neurons Jacob E. Rysted, Zhihong Lin, and Yuriy M. Usachev 9. Live Imaging of Mitochondrial ROS Production and Dynamic Redox Balance in Neurons Karolina Can, Sebastian Kьgler, and Michael Mьller 10. Monitoring of Permeability Transition Pore Openings in Isolated Individual Brain Mitochondria Nickolay Brustovetsky and Tatiana Brustovetsky 11. Examination of Mitochondrial Ion Conductance by Patch Clamp in Intact Neurons and Mitochondrial Membrane Preparations Elizabeth A. Jonas and Nelli Mnatsakanyan 12. Monitoring of Permeability Transition Pore Openings in Mitochondria of Cultured Neurons Tatiana Brustovetsky and Nickolay Brustovetsky 13. Protocols for Assessing Mitophagy in Neuronal Cell Lines and Primary Neurons Ruben K. Dagda and Monica Rice 14. Examining Mitochondrial Function at Synapses In Situ Gregory T. Macleod and Maxim V. Ivannikov 15. Proteomic Analysis of Neuronal Mitochondria Kelly L. Stauch and Howard S. Fox 16. Measuring Mitochondrial Pyruvate Oxidation Lawrence R. Gray, Alix A.J. Rouault, Lalita Oonthonpan, Adam J. Rauckhorst, Julien A. Sebag, and Eric B. Taylor
Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong Название: Mitochondrial Inhibitors and Neurodegenerative Disorders ISBN: 1468498215 ISBN-13(EAN): 9781468498219 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.
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