Автор: Justin C. St. John Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells ISBN: 1627038671 ISBN-13(EAN): 9781627038676 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Автор: John J. Lemasters; Anna-Liisa Nieminen Название: Mitochondria in Pathogenesis ISBN: 1475786956 ISBN-13(EAN): 9781475786958 Издательство: Springer Рейтинг: Цена: 32652.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson`s, Alzheimer`s, and Lou Gehrig`s disease.
Автор: Dejana Mokranjac; Fabiana Perocchi Название: Mitochondria ISBN: 149396822X ISBN-13(EAN): 9781493968220 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
A Guide to Computational Methods for Predicting Mitochondrial Localization.- Isolation of Functional Mitochondria from Cultured Cells and Mouse Tissues.- Isolation of Mitochondria From Saccharomyces Cerevisiae.- Isolation of Contact Sites Between Inner and Outer Mitochondrial Membranes.- Isolation Of Mitochondria-Associated Membranes (MAM) from Mouse Brain Tissue.- Label-Free Quantitative Analysis of Mitochondrial Proteomes using the Multienzyme Digestion-Filter Aided Sample Preparation (MED-FASP) and 'Total Protein Approach'.- Quantitative Analysis of Glycerophospholipids in Mitochondria by Mass Spectrometry.- Detection of Cysteine Redox States in Mitochondrial Proteins in Intact Mammalian Cells.- Chemical Crosslinking in Intact Mitochondria.- Reconstitution of Mitochondrial Membrane Proteins into Nanodiscs by Cell-Free Expression.- Detection of Dual Targeting and Dual Function of Mitochondrial Proteins in Yeast.- Localizing Mrnas Encoding Mitochondrial Proteins in Yeast by Fluorescence Microscopy and Subcellular Fractionation.- Assessing Mitochondrial Bioenergetics in Isolated Mitochondria from Various Mouse Tissues using Seahorse XF96 Analyzer.- Application of FRET-Based Biosensor "Ateam" for Visualization of ATP Levels in the Mitochondrial Matrix of Living Mammalian Cells.- A Microplate-Based Bioluminescence Assay of Mitochondrial Calcium Uptake.- New Imaging Tools to Analyze Mitochondrial Morphology in Caenorhabditis Elegans.- Single Molecule Tracking and Localization Of Mitochondrial Protein Complexes in Live Cells.- Analysis of Yeast Mitochondria by Electron Microscopy.- Analysis of Mitochondrial Membrane Protein Complexes by Electron Cryo-Tomography.- Assays for Mitophagy in Yeast.- Assessing Mitochondrial Selective Autophagy in the Nematode Caenorhabditis Elegans.- Assessing Mitochondrial Unfolded Protein Response in Mammalian Cells.- Analysis of Mitochondrial RNA-Processing Defects in Patient-Derived Tissues by Qrt-PCR and Rnaseq.- Identification of Disease-Causing Mutations by Functional Complementation of Patient-Derived Fibroblast Cell Lines.
Автор: James Whelan; Monika W. Murcha Название: Plant Mitochondria ISBN: 1493926381 ISBN-13(EAN): 9781493926381 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The chapters compiled in this detailed collection outline a number of methods used to study plant mitochondria today, starting from the isolation of mitochondria to detailed analyses of RNA, protein and enzymatic activities.
Автор: Hockenbery Название: Mitochondria and Cell Death ISBN: 1493936107 ISBN-13(EAN): 9781493936106 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material.
Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology, as well as those interested in the study of mitochondria and cell biology.
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