Stem Cells and Good Manufacturing Practices, Kursad Turksen

Автор: Anthony Atala
Название: Handbook of Stem Cells, vol.1-2
ISBN: 0123859425 ISBN-13(EAN): 9780123859426
Издательство: Elsevier Science
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Цена: 29722.00 р.
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Описание: Offers a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations. This title also offers advanced information of what is known about each specific organ system.

Автор: Ainscough
Название: Nuclear Reprogramming and Stem Cells
ISBN: 1617792241 ISBN-13(EAN): 9781617792243
Издательство: Springer
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Цена: 27950.00 р.
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Описание: Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states. Importantly, in addition to offering the opportunity to delve deeply into the mechanisms that drive disease aetiology the research is realistically opening the doors for development of targeted and personalized therapeutic applications that many considered, until recently, to be nothing more that a far fetched dream. This volume provides a timely glimpse into the methods that have been developed to instigate, and the mechanisms that have been identified to drive, the process of nuclear reprogramming, chronicling how the field has developed over the last 50-60 years. Since the early 1950s a small number of notable experiments have provided significant impetus to the field, primarily the demonstration of reprogramming ability, first by the complex cytoplasmic milieu that constitutes the amphibian egg, then that of the mammalian egg, and finally that of the mammalian embryonic stem cell. Most recently, the demonstration that a limited pool of defined molecules is capable of reprogramming a multitude of cell types has provided massive impetus and facilitated transition towards realistic therapeutic application. We have therefore reproduced some of the key articles that elegantly document these dramatic stages of development of the field in an inclusive appendix to the book, for the benefit of readers keen to investigate the history of how the field of stem cell biology has evolved.  Owing to the ever broadening nature of this field, and the incredible rate at which it is evolving, the main content of this volume focuses on areas that have shown significant movement in recent years, are most likely to translate into personalized therapeutic application, and thus provide greatest potential for significant impact on human health in the not too distant future. We recognize that research into many other disease states and cell types are all equally worthy of discussion. We would therefore like to acknowledge those researchers involved whose work we have not been able to include in this volume. Nuclear Reprogramming and Stem Cells will serve as a valuable resource for all researchers in the field of stem cell biology, including those just setting out on their career path as well as those already established in the field.

Автор: Randall J. Lee
Название: Stem Cells for Myocardial Regeneration
ISBN: 1493961268 ISBN-13(EAN): 9781493961269
Издательство: Springer
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Цена: 19564.00 р.
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Описание: The feld of regenerative medicine is in its infancy state. Enthusiasm for the potential of organ regeneration lies with the potential pluripotency of stem cells to differentiate into various tissue types. This volume of Methods in Molecular Biology will focus on the use of stem cells for myocardial repair and regeneration. The emphasis of this issue will be to provide basic scientists, translational investigators, and cardiologists a means to evaluate the effcacy and safety of stem cells in a standardized fashion for myocardial regeneration. Many different cell types have been considered for myocardial repair. Adult card- myocytes are unable to survive even when transplanted into normal myocardium. The use of fetal or neonatal cardiomyocytes is not a feasible source of cells due to ethical concerns and donor availability. Therefore, the use of pluripotent stem cells has become the focus of a cell source for myocardial repair and regeneration. A variety of stem cell types have been suggested to participate in myocardial repair. This has led the investigators to search for the “optimal cell type for myocardial repair”. Reliable isolation of the cell source with the ability to expand the cell population is a prerequisite. In the frst section of this book, methods for isolation of commonly used stem cells being investigated for myocardial regeneration are presented. Once a stem cell source has been selected, the stem cell needs to be tested in an app- priate animal model before being translated into clinical practice.

Автор: Ramiro Alberio
Название: Epiblast Stem Cells
ISBN: 1493960334 ISBN-13(EAN): 9781493960330
Издательство: Springer
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Цена: 14673.00 р.
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Описание: This book offers a detailed collection of techniques and protocols useful to the study of the biology of the pluripotent epiblast. It provides step-by-step detail essential for reproducible results and contains expert implementation advice.

Автор: Jeffrey M. Gimble; Bruce A. Bunnell
Название: Adipose-Derived Stem Cells
ISBN: 1493957813 ISBN-13(EAN): 9781493957811
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This comprehensive reference features experts from the field, including members of the International Federation of Adipose Therapeutics and Science (IFATS), who provide well defined protocols that further codify the applications of these powerful cells.

Автор: Baohong Zhang; Edmund J. Stellwag
Название: RNAi and microRNA-Mediated Gene Regulation in Stem Cells
ISBN: 149395749X ISBN-13(EAN): 9781493957491
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Recent stem cell research has revealed that miRNA and RNAi-mediated gene regulation is one of the vital determinates controlling the state of cell differentiation, with the small RNAs serving as key elements involved in regulatory network control of pluripotent cell fate determination. In RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications, expert authors from laboratories across the globe contribute an accessible compendium of up-to-date, proven methods focused on the study of the titular topic. Divided into three sections, the book first gives a brief introduction to RNAi and miRNAs in stem cells, with a focus on the current status of research and future perspectives, then it continues with detailed methods and protocols for RNAi screening, transfection, and the knockdown of specific genes and pathways in several animal species, including humans and mice, concluding with a section on recently developed methods for identification of miRNAs, including a general protocol for preparation and analysis of miRNA libraries for deep sequencing, knock down of a specific gene using miRNA-based shRNA, and miRNA expression analysis using qRT-PCR. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications serves as a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and the exciting areas of medicine, including regenerative medicine, aging, cancer, and neurological disorders, that can be advanced through this expanding area of research.

Автор: Philip H. Schwartz; Robin L. Wesselschmidt
Название: Human Pluripotent Stem Cells
ISBN: 149395802X ISBN-13(EAN): 9781493958023
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This authoritative book is as an ideal guide to scientists conducting their own pluripotent cell research programs. The book aims to assist those making strides in this field towards furthering human knowledge and, ultimately, improving the human condition.

Автор: Michal Amit; Joseph Itskovitz-Eldor
Название: Atlas of Human Pluripotent Stem Cells
ISBN: 1493957864 ISBN-13(EAN): 9781493957866
Издательство: Springer
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Цена: 19589.00 р.
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Описание: This comprehensive atlas offers step-by-step guidance for the derivation and culturing of human pluripotent stem cells in defined conditions and in non-adhesion suspension culture, as well as methods for examining pluripotency and karyotype stability.

Автор: Steven J. Shire; Wayne Gombotz; Karoline Bechtold-
Название: Current Trends in Monoclonal Antibody Development and Manufacturing
ISBN: 1461424917 ISBN-13(EAN): 9781461424918
Издательство: Springer
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Цена: 28732.00 р.
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Описание: This volume provides an understanding of the development, manufacturing techniques, and requirements of monoclonal antibodies. Covering one of the fastest growing areas of drug development, readers will find an informative text that describes the parameters for a successful regulatory submission.

Автор: Weichang Zhou; Anne Kantardjieff
Название: Mammalian Cell Cultures for Biologics Manufacturing
ISBN: 3662522705 ISBN-13(EAN): 9783662522707
Издательство: Springer
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Цена: 48913.00 р.
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Описание: Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Автор: Weichang Zhou; Anne Kantardjieff
Название: Mammalian Cell Cultures for Biologics Manufacturing
ISBN: 364254049X ISBN-13(EAN): 9783642540493
Издательство: Springer
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Цена: 39130.00 р.
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Описание: Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.

Автор: Goldenberg
Название: Resident Stem Cells and Regenerative Therapy,
ISBN: 0124160123 ISBN-13(EAN): 9780124160125
Издательство: Elsevier Science
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Цена: 21054.00 р.
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Описание: Stem cells have greatly impacted the scientific and lay communities, providing advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, cystic fibrosis, cirrhosis, and osteoporosis. This title presents the important factors to be considered when considering resident stem cells in regenerative therapies.