Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a "clone" with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically "relevant." This view has now changed quite dramatically thanks to the -omics revolution, particularly the advent of next generation DNA sequencing. Large-scale comparative genomic studies over the last few years have revealed that M. tuberculosis clinical strains are more genetically diverse than appreciated previously. Moreover, an increasing number of experimental and epidemiological studies are showing that this genetic diversity also translates into important phenotypic variation. Taken together, these findings have led to a paradigm shift, such that currently phylogenetic diversity among M. tuberculosis clinical strains is being considered in the development of new tools to combat tuberculosis. The purpose of this book is to bring together a series of contributions from some of the most influential groups working on various aspects of M. tuberculosis diversity, and which through their work have contributed to the this paradigm shift. This includes authors focusing on the evolution of M. tuberculosis in relation to other members of the M. tuberculosis complex adapted to animals, the co-evolution between M. tuberculosis and humans, the phenotypic consequences of strains diversity both from an experimental and epidemiological point of view, the ecology and evolution of drug resistant tuberculosis, the diversity and evolution of the BCG vaccine strains, and the use of mathematical modelling to study strain diversity and drug resistance in human tuberculosis. No such book has ever been published, and given the paradigm shift described above, this book will be a valuable resource both for established researchers as well as new scientists, clinicians and public health officials joining the growing field of tuberculosis research.
Описание: With contributions from an interdisciplinary team of recognized experts, this illustrated volume reviews the diverse mechanisms-genetic, metabolic, and molecular-that give M. tuberculosis its antibiotic-resistant virulence and allow it to evade immune systems.
Автор: Mauro Bendinelli; Herman Friedman Название: Mycobacterium tuberculosis ISBN: 146845420X ISBN-13(EAN): 9781468454208 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Tuberculosis once again occupies a special position in the areas of infec- tious diseases and microbiology. Koch`s postulates were developed with tuberculosis in mind and became a focal point for many advances in microbiology and medicine.
Автор: B. Rowe Byers Название: Iron Acquisition by the Genus Mycobacterium ISBN: 331900302X ISBN-13(EAN): 9783319003023 Издательство: Springer Рейтинг: Цена: 9794.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin.
Автор: Howard Goldfine; Hao Shen Название: Listeria monocytogenes: Pathogenesis and Host Response ISBN: 1489992677 ISBN-13(EAN): 9781489992673 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: During the past twenty years Listeria monocytogenes has emerged as one of the most intensely studied bacterial pathogens. New windows are constantly being opened into the complexity of host cell biology and the interplay of the signals connecting the various cells and organs involved in the host response.
Автор: A. L. Notkins; M. B. A. Oldstone Название: Concepts in Viral Pathogenesis ISBN: 1461297567 ISBN-13(EAN): 9781461297567 Издательство: Springer Рейтинг: Цена: 11101.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest.
Описание: There are three major types of human retroviruses, namely HIV, HTLV, and endogenous human retroviruses. This book presents the various findings on the replication of these human retroviruses. It is suitable for students, researchers and medical professionals.
Автор: Gregory Название: Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy ISBN: 3319394045 ISBN-13(EAN): 9783319394046 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews.
Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Автор: Pontus Nordenfelt; Mattias Collin Название: Bacterial Pathogenesis ISBN: 1493966715 ISBN-13(EAN): 9781493966714 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume discusses various methods and protocols used for the experimentation of a wide range of bacterial species, such as Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumonia, Listeria monocytogenes, and Mycobacterium marinum. Bacterial Pathogens: Methods and Protocols is divided into 6 parts: Part 1 describes different approaches to identifying and characterizing bacterial effector molecules; Part 2 deals with structural biology of bacterial pathogenesis and how to overcome folding and stability problems with recombinantly expressed proteins; Part 3 details methodology that identifies bacteria in complex communities and how genomes of bacterial pathogens have evolved; Part 4 reflects on the rapid development of advanced imaging techniques that address questions about molecular properties of individual live bacteria, ultrastructure of surfaces, and subcellular localization of bacterial proteins; Part 5 describes methods from in vitro and in vivo modeling of bacterial infections; and Part 6 explores how bacterial pathogens are the true experts of the immune system. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Bacterial Pathogens: Methods and Protocols is a valuable resource for anyone who is interested in this fascinating and evolving field.
Автор: Eduardo A. Groisman Название: Principles of Bacterial Pathogenesis, ISBN: 0123042208 ISBN-13(EAN): 9780123042200 Издательство: Elsevier Science Рейтинг: Цена: 15748.00 р. Наличие на складе: Поставка под заказ.
Описание: Presents a molecular perspective on a group of bacterial pathogens. It explains the principles of bacterial pathogenesis and covers diverse aspects integrating regulation, cellular microbiology and evolution of microbial disease of humans. It provides general perspectives on the evolution, regulation, and secretion of virulence and determinants.
Автор: Nathanson Название: Viral Pathogenesis and Autoimmunity.2002 ISBN: 0781711037 ISBN-13(EAN): 9780781711036 Издательство: Lippincott Williams & Wilkins Цена: 8237.00 р. Наличие на складе: Поставка под заказ.
Описание: Written by eminent authorities on viral pathogenesis and immunity, this text provides a coherent, concise introduction to the field. The authors focus on fundamental principles and present a well-organized overview that is easy for readers to absorb.Section 1, essentials of viral pathogenesis , describes the sequential events in viral infection, the localization of viral infections, and the variety of virus-cell interactions.Section 2, host responses to viral infection , examines immune responses, including virus-induced immunopathology and immunosuppression.Section 3, virus-host interactions , covers virulence, viral persistence, virus-induced oncogenesis, and host susceptibility.Section 4, prevention of viral infections , explains the key principles of vaccine development.
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