Gene Therapy for Neurological Disorders, Fredric P. Manfredsson

Автор: Fredric P. Manfredsson
Название: Gene Therapy for Neurological Disorders
ISBN: 1493932705 ISBN-13(EAN): 9781493932702
Издательство: Springer
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Описание:

Part I Introduction

1. Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System
Frederic P. Manfredsson

Part II Expression Cassettes

2. Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors
Matthew L. Hirsch, Sonya J. Wolfe, and R. J. Samulski

3. Expression of Multiple Functional RNAs or Proteins from One Viral Vector
Tomas Bjцrklund

4. Regulated Gene Therapy
Ludivine Breger, Erika Elgstrand Wettergren, Luis Quintino, and Cecilia Lundberg

5. Design of shRNA and miRNA for Delivery to the CNS
Gabriela Toro and Christian Mueller

6. Tissue Specific Promoters in the CNS
Sebastian Kьgler

Part III Viral Vector Production

7. Small Scale Recombinant Adeno-Associated Virus Purification
Corinna Burger and Kevin Nash

8. Lentivirus Production and Purification
Matthew J. Benskey and Frederic P. Manfredsson

9. Viral Vector Production: Adenovirus
Julius W. Kim, Ramin A. Morshed, J. Robert Kane, Brenda Auffinger, Jian Qiao, and Maciej S. Lesniak

Part IV Viral Vector Tropism

10. Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids
Michael J. Castle, Heikki T. Turunen, Luk H. Vandenberghe, and John H. Wolfe

11. Altering Tropism of rAAV by Directed Evolution
Damien Marsic and Sergei Zolotukhin

12. Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins
Kenta Kobayashi, Shigeki Kato, Ken0ichi Inoue, Masahiko Takada, and Kazuto Kobayashi

13. Directed Evolution of Adenoviruses
Jason G. Smith

Part V Delivery Methods

14. Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling
Matthew J. Benskey and Frederic P. Manfredsson

15. MRI-Guided Delivery of Viral Vectors
Ernesto A. Salegio, John Bringas, Krystof S. Bankiewicz

16. Systemic Gene Therapy for Targeting the CNS
Sara E. Gombash and Kevin D. Foust

17. Widespread Neuronal Transduction of the Rodent CNS via Neonatal Viral Injection
Ji-Yoen Kim, Stacy D. Grunke, and Joanna L. Jankowsky

18. AAV-Mediated Gene Transfer to Dorsal Root Ganglion
Hongwei Yu, Gregory Fischer, and Quinn H. Hogan

19. Gene Therapy of the Peripheral Nervous System: The Enteric Nervous System
Matthew J. Benskey and Frederic P. Manfredsson

20. Gene Therapy of the Peripheral Nervous System: Celiac Ganglia

21. Convection Enhanced Delivery of Recombinant Adeno-Associated Virus into the Mouse Brain
Kevin R. Nash and Marcia N. Gordon

22. Non-Viral Gene Therapy of the Nervous System: Electroporation
XueFeng Ding and Ming Fan

23. Non-Viral, Lipid-Mediated DNA and mRNA Gene Therapy of the Central Nervous System (CNS): Chemical-Based Transfection
James G. Hecker

24. Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model
Masatoshi Suzuki and Clive N. Svendsen

Part VI Gene-Therapy Based Modeling of Neurodegenerative Disorders

25. Gene Therapy Models of Alzheimer's Disease and Other Dementias
Benjamin Combs, Andrew Kneynsberg, and Nicholas M. Kanaan

26. Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease
D. Luke Fischer, Sara E. Gombash, Christopher J. Kemp, Frederic P. Manfredsson, Nicole K. Polinski, Megan F. Duffy, and Caryl E. Sortwell

27. Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington's Disease
Deborah Young

Part VII Gene-Therapy for the Treatment of Neurological Disorders

28. Gen

Автор: E. Antonio Chiocca; Xandra O. Breakefield
Название: Gene Therapy for Neurological Disorders and Brain Tumors
ISBN: 1475753144 ISBN-13(EAN): 9781475753141
Издательство: Springer
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Цена: 26122.00 р.
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Описание: Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology.

Автор: Larner
Название: A Dictionary of Neurological Signs
ISBN: 1441970940 ISBN-13(EAN): 9781441970947
Издательство: Springer
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Цена: 6288.00 р.
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Описание: The first two editions of the Dictionary of Neurological Signs were very well-received by readers and reviewers alike. Like those editions, this Third Edition, updated and expanded, can be almost as well described in terms of what the book is not, along with details about what it is. The Dictionary is not a handbook for treatment of neurological disorders. While many entries provide the latest treatment options, up-to-the-minute therapies are not discussed in bedside level detail. The Dictionary is not a board review book because it is not in Q&A format but could easily serve in that capacity since each entry is a fairly complete snapshot of a specific disorder or disease. The Dictionary is an alphabetical listing of commonly presenting neurological signs designed to guide the physician toward the correct clinical diagnosis. The Dictionary is focused, problem-based, concise and practical. The structured entries in this practical, clinical resource provide a thumbnail of a wide range of neurological signs. Each entry includes: • A definition of the sign • A brief account of the clinical technique required to elicit the sign • A description of the other signs which may accompany the index sign • An explanation of pathyophysiological and/or pharmacological background • Differential diagnosis • Brief treatment details Where known, these entries also include the neuroanatomical basis of the sign. The Dictionary of Neurological Signs, Third Edition, is an indispensable reference for all students, trainees, and clinicians who care for patients with neurological disorders.

Автор: Basabdatta Sen Bhattacharya; Fahmida N. Chowdhury
Название: Validating Neuro-Computational Models of Neurological and Psychiatric Disorders
ISBN: 3319200364 ISBN-13(EAN): 9783319200361
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book is a collection of articles by leading researchers working at the cutting edge of neuro-computational modelling of neurological and psychiatric disorders. Each article contains model validation techniques used in the context of the specific problem being studied. Validation is essential for neuro-inspired computational models to become useful tools in the understanding and treatment of disease conditions. Currently, the immense diversity in neuro-computational modelling approaches for investigating brain diseases has created the need for a structured and coordinated approach to benchmark and standardise validation methods and techniques in this field of research. This book serves as a step towards a systematic approach to validation of neuro-computational models used for studying brain diseases and should be useful for all neuro-computational modellers.

Автор: Raphael Pinaud; Liisa A. Tremere
Название: Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders
ISBN: 1489987436 ISBN-13(EAN): 9781489987433
Издательство: Springer
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Цена: 22201.00 р.
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Описание: This book provides a compilation of the most up-to-date literature on the topic of immediate early genes (IEGs). It reviews and details experiments and theories that challenge the reader to expand their view on how IEG research is currently being used to advance our understanding of static and active brain circuits.

Автор: Bart Demaerschalk,Dean Wingerchuk
Название: Evidence–Based Neurology: Management of Neurological Disorders
ISBN: 0470657782 ISBN-13(EAN): 9780470657782
Издательство: Wiley
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Цена: 16307.00 р.
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Описание: From an expert editor team drawn from the Cochrane Neurological Network, Evidence-Based Neurology provides specialists and those in training with the skills and knowledge to apply evidence-based practice in the clinical setting.

Автор: Millichap, J. Gordon
Название: Neurological SyndromesA Clinical Guide to Symptoms and Diagnosis
ISBN: 1461477859 ISBN-13(EAN): 9781461477853
Издательство: Springer
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Цена: 11179.00 р.
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Описание: This book offers a concise resource for understanding how a group of neurologic symptoms or signs collectively characterize a disease or disorder. It provides a definition of each syndrome that includes diagnostic characteristics and genetic considerations.

Автор: Michael P. Barnes
Название: Neurological Rehabilitation,110
ISBN: 0444529012 ISBN-13(EAN): 9780444529015
Издательство: Elsevier Science
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Цена: 32002.00 р.
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Описание: Covers the basic principles of neurorehabilitation, including excellent chapters on learning and skill acquisition, outcome measurement and functional neuroimaging. This title includes reviews on the management of the main neurological disabling physical problems, such as spasticity, pain, sexual functioning and dysphagia.

Автор: Rana, Abdul Qayyum, Morren, John Anthony
Название: Neurological Emergencies in Clinical Practice
ISBN: 1447151909 ISBN-13(EAN): 9781447151906
Издательство: Springer
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Цена: 11878.00 р.
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Описание: It is useful in several settings including the emergency room, hospital in-patient service as well as the intensive care unit.Neurological Emergencies in Clinical Practice has a wide appeal and relevance to disciplines including neurology, emergency medicine, critical care medicine, internal medicine and family medicine.

Автор: Xuenong Bo; Joost Verhaagen
Название: Gene Delivery and Therapy for Neurological Disorders
ISBN: 1493923056 ISBN-13(EAN): 9781493923052
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors` laboratories.

Автор: Autumn Klein
Название: Neurological Illness in Pregnancy: Principles and Practice
ISBN: 0470670436 ISBN-13(EAN): 9780470670439
Издательство: Wiley
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Цена: 14565.00 р.
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Описание: This book is a practical and easily readable guide for neurologists, obstetricians, and primary care doctors treating female patients with neurological illness in their reproductive years.Neurological illness before and during pregnancy is reasonably common and much of the care provided for pregnant patients with a neurological illness is through experience and anecdotal treatments. This title consolidates the information available into one concise resource written by a specialist team who deal with pregnant women with neurological issues every day. The most frequent neurological illnesses in women of reproductive age are headache, epilepsy, and multiple sclerosis, plus there can be frequent neurological complications for women in pregnancy, including peripheral neuropathies. The text covers these major subspecialties in neurology as well as anesthesia, radiology, and neurosurgical issues that are encountered in pregnancy.The eighteen chapters in this title cover brief descriptions of epidemiology, disease symptoms, evaluation, treatment, and any other special considerations for that topic. Multiple tables and summaries illustrate each topic with a focus on providing the reader with concise, practical information for everyday use. This title: Provides a practical guide to treating female patients with neurological illness in their reproductive years Offers wide ranging coverage, including family planning and lactation Presents information in approachable tables and summaries, focusing on high yield information useful for clinical consultation Is written by a team of experts and edited by recognized leaders in the field An essential resource for all physicians treating patients with neurological disease who are pregnant, or who are planning to become pregnant, and for those interested in women s neurology. In Memory of Dr. Autumn KleinThe creation of this textbook was initiated by Dr. Autumn Klein, a pioneer of Women s Neurology. She developed the format, and carefully chose the authors from an elite group of specialists from across the United States and abroad. She unexpectedly passed away on April 17, 2013 before the completion of the book. In her memory, the authors of the book chose to complete the textbook as a legacy to her passion for the field of Women s Neurology. Autumn is fondly remembered for her selfless devotion to the patients for whom she cared. She made herself available for consultation on obstetrical patients 24/7. It was always reassuring to have her respond to an unexpected neurologic event. She educated her patients about their neurologic disease and about what to expect during pregnancy and motherhood. She collaborated extensively with obstetricians, anesthesiologists, and epilepsy staff to provide comprehensive patient care. With this first edition of Neurologic Illness in Pregnancy we hope that Autumn s vision will be fulfilled and that it will create a legacy that carries on for generations to come.