Nuclear Reprogramming, Nathalie Beaujean; H?l?ne Jammes; Alice Jouneau

Автор: Ainscough
Название: Nuclear Reprogramming and Stem Cells
ISBN: 1617792241 ISBN-13(EAN): 9781617792243
Издательство: Springer
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Цена: 27950.00 р.
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Описание: Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states. Importantly, in addition to offering the opportunity to delve deeply into the mechanisms that drive disease aetiology the research is realistically opening the doors for development of targeted and personalized therapeutic applications that many considered, until recently, to be nothing more that a far fetched dream. This volume provides a timely glimpse into the methods that have been developed to instigate, and the mechanisms that have been identified to drive, the process of nuclear reprogramming, chronicling how the field has developed over the last 50-60 years. Since the early 1950s a small number of notable experiments have provided significant impetus to the field, primarily the demonstration of reprogramming ability, first by the complex cytoplasmic milieu that constitutes the amphibian egg, then that of the mammalian egg, and finally that of the mammalian embryonic stem cell. Most recently, the demonstration that a limited pool of defined molecules is capable of reprogramming a multitude of cell types has provided massive impetus and facilitated transition towards realistic therapeutic application. We have therefore reproduced some of the key articles that elegantly document these dramatic stages of development of the field in an inclusive appendix to the book, for the benefit of readers keen to investigate the history of how the field of stem cell biology has evolved.  Owing to the ever broadening nature of this field, and the incredible rate at which it is evolving, the main content of this volume focuses on areas that have shown significant movement in recent years, are most likely to translate into personalized therapeutic application, and thus provide greatest potential for significant impact on human health in the not too distant future. We recognize that research into many other disease states and cell types are all equally worthy of discussion. We would therefore like to acknowledge those researchers involved whose work we have not been able to include in this volume. Nuclear Reprogramming and Stem Cells will serve as a valuable resource for all researchers in the field of stem cell biology, including those just setting out on their career path as well as those already established in the field.

Автор: Justin Ainscough; Shinya Yamanaka; Takashi Tada
Название: Nuclear Reprogramming and Stem Cells
ISBN: 162703904X ISBN-13(EAN): 9781627039048
Издательство: Springer
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Цена: 21661.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states. Importantly, in addition to offering the opportunity to delve deeply into the mechanisms that drive disease aetiology the research is realistically opening the doors for development of targeted and personalized therapeutic applications that many considered, until recently, to be nothing more that a far fetched dream. This volume provides a timely glimpse into the methods that have been developed to instigate, and the mechanisms that have been identified to drive, the process of nuclear reprogramming, chronicling how the field has developed over the last 50-60 years. Since the early 1950s a small number of notable experiments have provided significant impetus to the field, primarily the demonstration of reprogramming ability, first by the complex cytoplasmic milieu that constitutes the amphibian egg, then that of the mammalian egg, and finally that of the mammalian embryonic stem cell. Most recently, the demonstration that a limited pool of defined molecules is capable of reprogramming a multitude of cell types has provided massive impetus and facilitated transition towards realistic therapeutic application. We have therefore reproduced some of the key articles that elegantly document these dramatic stages of development of the field in an inclusive appendix to the book, for the benefit of readers keen to investigate the history of how the field of stem cell biology has evolved. Owing to the ever broadening nature of this field, and the incredible rate at which it is evolving, the main content of this volume focuses on areas that have shown significant movement in recent years, are most likely to translate into personalized therapeutic application, and thus provide greatest potential for significant impact on human health in the not too distant future. We recognize that research into many other disease states and cell types are all equally worthy of discussion. We would therefore like to acknowledge those researchers involved whose work we have not been able to include in this volume. Nuclear Reprogramming and Stem Cells will serve as a valuable resource for all researchers in the field of stem cell biology, including those just setting out on their career path as well as those already established in the field.

Автор: Alexander Meissner; J?rn Walter
Название: Epigenetic Mechanisms in Cellular Reprogramming
ISBN: 3662510626 ISBN-13(EAN): 9783662510629
Издательство: Springer
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Цена: 16977.00 р.
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Описание: Offering an overview of current topics and concepts concerning mechanisms and consequences of epigenetic reprogramming, this book addresses biomedical researchers in search of more detailed knowledge of novel mechanisms and methods of study.

Автор: Sheng Ding
Название: Cellular Programming and Reprogramming
ISBN: 1493957147 ISBN-13(EAN): 9781493957149
Издательство: Springer
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Цена: 16070.00 р.
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Описание: Before the therapeutic potential of cell replacement therapy or the development of therapeutic drugs for stimulating the body’s own regenerative ability to repair cells damaged by disease and injury can be fully realized, control of stem cell fate, immuno-rejection, and limited cell sources must be overcome. In Cellular Programming and Reprogramming: Methods and Protocols, expert researchers cover the most recent technologies and their related mechanisms involved in the programming and reprogramming of cell fate. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, laboratory protocols, and notes to highlight tips on troubleshooting and avoiding known pitfalls. Essential and cutting-edge, Cellular Programming and Reprogramming: Methods and Protocols promises to aid scientists attempting to advance stem cell biology in order to better treat devastating human diseases, including cardiovascular disease, neurodegenerative disease, musculoskeletal disease, diabetes, and cancer.

Автор: Xiaoyuan Wang; Jian Chen; Peter Quinn
Название: Reprogramming Microbial Metabolic Pathways
ISBN: 9400792433 ISBN-13(EAN): 9789400792432
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.

Автор: Acelya Yilmazer
Название: In Vivo Reprogramming in Regenerative Medicine
ISBN: 3319657194 ISBN-13(EAN): 9783319657196
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This new volume reviews current progress on different approaches of in vivo reprogramming technology.