Single Molecule Enzymology, Gregory I. Mashanov; Christopher Batters

Автор: Spies, Maria
Название: Methods in Enzymology
ISBN: 012809267X ISBN-13(EAN): 9780128092675
Издательство: Elsevier Science
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Описание: Single-Molecule Enzymology, Part A, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in single-molecule enzymology, and includes sections on such topics as force-based and hybrid approaches, fluorescence, high-throughput sm enzymology, nanopores, and tethered particle motion.

Автор: Jon Lorsch
Название: Laboratory Methods in Enzymology: Protein Part D,552
ISBN: 0128002794 ISBN-13(EAN): 9780128002797
Издательство: Elsevier Science
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Описание:

The critically acclaimed laboratory standard for almost 50 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 520 volumes and 40,000 chapters in the collection, much of the material is still relevant today and is truly an essential publication for researchers in all fields of life sciences, including microbiology, biochemistry, cancer research, and genetics, just to name a few.

Автор: Alexander E. Knight
Название: Single Molecule Biology,
ISBN: 0123742277 ISBN-13(EAN): 9780123742278
Издательство: Elsevier Science
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Описание: Describes such single molecule techniques (that allow for manipulation and measurement of single biological molecules within a live cell) as single molecule fluorescence, optical tweezers, and scanning probe microscopy. This book is organized by biological system or molecule. It discusses applications in molecular diagnostics and drug discovery.

Автор: Henry Weiner; David W. Crabb; T. Geoffrey Flynn
Название: Enzymology and Molecular Biology of Carbonyl Metabolism 4
ISBN: 1461362598 ISBN-13(EAN): 9781461362593
Издательство: Springer
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Описание: The Sixth International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism was held outside of Dublin, Ireland at the end of June, 1992. During the past decade site directed mutagenesis to probe for the active site of an enzyme has become part of traditional enzymology;

Автор: Greg Lever
Название: Large-Scale Quantum-Mechanical Enzymology
ISBN: 3319193503 ISBN-13(EAN): 9783319193502
Издательство: Springer
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Описание: This work establishes linear-scaling density-functional theory (DFT) as a powerful tool for understanding enzyme catalysis, one that can complement quantum mechanics/molecular mechanics (QM/MM) and molecular dynamics simulations. The thesis reviews benchmark studies demonstrating techniques capable of simulating entire enzymes at the ab initio quantum-mechanical level of accuracy. DFT has transformed the physical sciences by allowing researchers to perform parameter-free quantum-mechanical calculations to predict a broad range of physical and chemical properties of materials. In principle, similar methods could be applied to biological problems. However, even the simplest biological systems contain many thousands of atoms and are characterized by extremely complex configuration spaces associated with a vast number of degrees of freedom. The development of linear-scaling density-functional codes makes biological molecules accessible to quantum-mechanical calculation, but has yet to resolve the complexity of the phase space. Furthermore, these calculations on systems containing up to 2,000 atoms can capture contributions to the energy that are not accounted for in QM/MM methods (for which the Nobel prize in Chemistry was awarded in 2013) and the results presented here reveal profound shortcomings in said methods.