Описание: Deals with breakthroughs in ion-channel research that have been brought about by joint efforts of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these designed biomolecules. This book is aimed at researchers in nanodevices and biosensors, undergraduate and graduate students in biology.
Автор: N. Rama Krishna; Lawrence J. Berliner Название: Structure Computation and Dynamics in Protein NMR ISBN: 0306459531 ISBN-13(EAN): 9780306459535 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Covers the developments in molecular modeling on the basis of spectroscopic or diffraction data, pulse sequences and computational methods for automated assignment and structure determination, structure calculation of symmetric oligomer proteins, and structure refinement by hybrid-hybrid matrix method from 3D NOESY-NOESY data.
Автор: Jean-Jacques Lacapere Название: Membrane Protein Structure and Function Characterization ISBN: 1493971492 ISBN-13(EAN): 9781493971497 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this present volume, different approaches are detailed to produce membrane proteins, purify them, study their function, determine their structure, and model them in membrane.
Автор: N. Rama Krishna; Lawrence J. Berliner Название: Structure Computation and Dynamics in Protein NMR ISBN: 1475781725 ISBN-13(EAN): 9781475781724 Издательство: Springer Рейтинг: Цена: 41925.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Volume 17 is the second in a special topic series devoted to modern techniques in protein NMR, under the Biological Magnetic Resonance series.
Автор: Wolfgang B. Fischer Название: Viral Membrane Proteins: Structure, Function, and Drug Design ISBN: 1441934537 ISBN-13(EAN): 9781441934536 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The range of information covered includes signal proteins, ion channels, and fusion proteins.This book has a place in the libraries of researchers and scientists in a wide array of fields, including protein chemistry, molecular biophysics, pharmaceutical science and research, bioanotechnology, molecular biology, and biochemistry.
Описание: Structure and Dynamics of Biomolecules is a manual describing the principles behind various types of experiments on biological samples using synchrotron radiation or neutrons and provides the technical understanding needed for interpreting the data collected. It is based on the HERCULES lecture series.
Автор: Marina V. Rodnina; Wolfgang Wintermeyer; Rachel Gr Название: Ribosomes Structure, Function, and Dynamics ISBN: 3709119286 ISBN-13(EAN): 9783709119280 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. The up-to-date reviews will serve as a source of essential information.
Описание: With chapters contributed by leading scientists from 20 research groups worldwide, this volume provides an overview of modern computer-based techniques to compute the structure, properties, and dynamics of biomolecules and biomolecular processes.
Описание: This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: * Expression screening using fluorescent proteins * The use of detergents in membrane protein research * The use of NMR * Synchrotron developments in membrane protein structural biology * Visualisation and X-ray data collection of microcrystals * X-ray diffraction data analysis from multiple crystals * Serial millisecond crystallography * Serial femtosecond crystallography * Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.
Автор: Jean-Jacques Lacap?re Название: Membrane Protein Structure Determination ISBN: 1493961179 ISBN-13(EAN): 9781493961177 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Part I: Membrane Protein Purification 1. Characterization of Membrane Protein Preparations: Measurement of Detergent Content and Ligand Binding after Proteoliposomes Reconstitution Mariano A. Ostuni, Soria Iatmanen, David Teboul, Jean-Claude Robert, and Jean-Jacques Lacapиre 2. Native Membrane Proteins Versus Yeast Recombinant: An Example, the Mitochondrial ADP/ATP Carrier Bertrand Arnou, Cйcile Dahout-Gonzalez, Ludovic Pelosi, Guy J.-M. Lauquin, Gйrard Brandolin, and Vйronique Trйzйguet 3. Bacterial Overexpressed Membrane Proteins: An Example, the TSPO Jean-Claude Robert and Jean-Jacques Lacapиre 4. Insect Cell Versus Bacterial Overexpressed Membrane Proteins: An Example, the Human ABCG2 Transporter Alexandre Pozza, Josй M. Perez-Victoria, and Attilio Di Pietro Part II: X-Ray Crystallography 5. Crystallography of Membrane Proteins: From Crystallization to Structure Aurйlien Deniaud, Ekaterina Moiseeva, Valentin Gordeliy, and Eva Pebay-Peyroula 6. Structural Approaches of the Mitochondrial Carrier Family Hughes Nury, Iulia Blesneac, Stephanie Ravaud, and Eva Pebay-Peyroula 7. What Can Be Learned about the Function of a Single Protein from Its Various X-Ray Structures: The Example of the Sarcoplasmic Calcium Pump Jesper Vuust M ller, Claus Olesen, Anne-Marie Lund Winther, and Poul Nissen 8. Toward Drug Design: Recent Progress in the Structure of GPCR, a Membrane Protein with High Potential as a Pharmaceutical Target Vadim Cherezov, Enrique Abola, and Raymond C. Stevens Part III: Electron Microscopy 9. Observation of Membrane Proteins in situ: AQPcic, the Insect Aquaporin Example Daniel Thomas and Annie Cavalier 10. Two-Dimensional Crystallization of Integral Membrane Proteins for Electron Crystallography David L. Stokes, William J. Rice, Minghui Hu, Changki Kim, and Iban Ubarretxena 11. Structure Determination of Membrane Protein by Both Cryo Electron Tomography and Single Particle Analysis Sylvain Trйpout, Jean-Christophe Taveau, and Olivier Lambert 12. Electron Microscope Tomography of Native Membranes Gabriel Pйranzi, Cedric Messaoudi, Leeyah Issop, and Jean-Jacques Lacapиre 13. From Electron Microscopy Maps to Atomic Structures Using Normal Mode-Based Fitting Konrad Hinsen, Edward Beaumont, Bertrand Fournier, and Jean-Jacques Lacapиre Part IV: Nuclear Magnetic Resonance 14. Determination of Membrane Protein Structures Using Solution and Solid-State NMR Pierre Montaville and Nadиge Jamin 15. Membrane Protein Fragments Reveal Both Secondary and Tertiary Structure of Membrane Proteins Philip L. Yeagle and Arlene D. Albert 16. What Can We Learn From a Small Regulatory Membrane Protein? Gianluigi Veglia, Kim N. Ha, Lei Shi, Raffaello Verardi, and Nathaniel J. Traaseth 17. Solution-State NMR Spectroscopy for Investigating 3D Structure of Membrane Proteins in Detergent Micelles: Structure of the Klebsiella pneumoniae Outer Membrane Protein, KpOmpA Marie Renault, Olivier Saurel, Pascal Demange, Virginie Reat, and Alain Milon 18. NMR Spectroscopy of Lipid Bilayers Axelle Grйlard, Cйcile Loudet, Anna Diller, and Erick J. Dufourc Part V: Molecular Modelling 19. Critical Review of General Guidelines for Membrane Proteins Model Building and Analysis Catherine Etchebest and Gaelle Debret 20. 3D-Structural Models of Transmembrane Proteins Alexandre G. de Brevern 21. Molecular Dynamics of Membrane Peptides and Proteins: Principles and Comparison to Experimental Data Patrick F.J. Fuchs 22. Membrane Protein Dynamics from Femtoseconds to Seconds Christian Kandt and Luca Monticelli 23. The Family of G Protein-Coupled Receptors: An Example of Membrane Proteins Irina G. Tikhonova and Daniel Fourmy
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