Описание: As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical.
Автор: Judit Ov?di; Ferenc Orosz Название: Protein folding and misfolding: neurodegenerative diseases ISBN: 9048181275 ISBN-13(EAN): 9789048181278 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson`s and Alzheimer`s diseases.
Описание: This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
Автор: Schapira Название: Neurodegeneration ISBN: 0470672684 ISBN-13(EAN): 9780470672686 Издательство: Wiley Рейтинг: Цена: 21693.00 р. Наличие на складе: Поставка под заказ.
Описание: This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject.
Автор: Werner Poewe; Gerhard Ransmayr Название: Advances in Research on Neurodegeneration ISBN: 3211832610 ISBN-13(EAN): 9783211832615 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: th From November 20 to 23, 1997 the 6 International Winter Conference on Neurodegeneration was held in Kitzbtihel, Austria, to explore recent ad- vances in the treatment of neurodegenerative and neuroimmunological CNS diseases. Following the tradition of the previous conferences a select group of distinguished basic researchers and clinicians spent two days in the quiet Austrian mountain resort with in depth review and discussion of current topics in the fields of neurodegeneration and neuroimmunology focussing on the interface between these two groups of disorders. The main focus was on how to develop new treatment strategies based on current understandings in the molecular biology of maturation of the nervous system and of basic processes governing neurodegenerative disorders, like Parkinson's disease, multiple system atrophy, Huntington's disease and amyotrophic lateral scle- rosis as well as CNS demyelination in multiple sclerosis. Starting from classical concepts of symptomatic dopamine replacement therapy in Parkinson's dis- ease, state-of-the-art lectures covered new evolving therapeutic concepts for neurodegenerative disorders: somatic gene therapy, neural transplantation and neuroprotection through pharmacological treatment as well as through deep brain stimulation. The emphasis on restoration as key feature of future neurological therapy was also highlighted in a session on mechanisms of demyelination and strate- gies for myelin repair in neurological autoimmune disease. The present volume includes updated review articles and original papers th covering the proceedings of the 6 International Winter Conference.
Название: Neuroinflammation and Neurodegeneration ISBN: 1493910701 ISBN-13(EAN): 9781493910700 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.
Автор: R. Horowski; Y. Mizuno; C.W. Olanow; W. Poewe; P. Название: Advances in Research on Neurodegeneration ISBN: 3211839070 ISBN-13(EAN): 9783211839072 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: P. Riederer; D.B. Calne; R. Horowski; Y. Mizuno; C Название: Advances in Research on Neurodegeneration ISBN: 3211835377 ISBN-13(EAN): 9783211835371 Издательство: Springer Рейтинг: Цена: 29209.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The 8th International Winter Conference on Neurodegeneration from Febru- ary 9 to 13, 2000 took place in Tegernsee, Bavaria, Germany. The interest shown in this symposium, which was carried by invited speakers only, was striking. 28 lectures in 5 sessions dealt with themes on basic science and therapy strategies for neurodegenerative illness. This time especially basic mechanism of cell death and resulting causal treatment possibilities were centre themes of the lectures and lively discussions. In accordance with tradi- tion 5 lectures on Multiple Sclerosis finished the convention. 60 scientists from 13 countries discussed current questions to these themes. The Symposium started with a lecture on the history of the develop- ment of modern-L-DOPA-therapy. Lectures on cell death of dopaminergic nerve cells, new valuation regarding assembly, built up and function of neuromelanin of Substantia nigra and with this, the question of the physio- logic and pathobiochemical role of dopamine and neuromelanin built the first block of themes which consequently extended to molecular and genetic aspects of cell death. Highlights of the symposium were neuroprotective and neuroregenerative future therapy strategies together with discussions on the difficulties of clinical neuroprotection. Developmental biological aspects on nerve cells, reorganisation and neurodegeneration showed a stimulating point of view of momentary and future development possibilities of new and more causal forms of therapy of neurodegenerative illness.
Автор: Y. Mizuno; M.B.H. Youdim; D.B. Calne; R. Horowski; Название: Advances in Research on Neurodegeneration ISBN: 3211829342 ISBN-13(EAN): 9783211829349 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Alzheimer`s disease is the leading cause of dementia in the elderly people and Parkinson`s disease is one of the major neurologic disorders with the prevalence between 1 and 2/1 000 population in advanced countries. even in Parkinson`s disease, still it is impossible to slow down the disease process with the currently available treatment.
Автор: Baekelandt, Veerle Название: Disease-Modifying Targets in Neurodegenerative Disorders ISBN: 0128051205 ISBN-13(EAN): 9780128051207 Издательство: Elsevier Science Рейтинг: Цена: 11706.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.
This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.
Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
Summarizes how patients are treated today, providing a glance at future disease management
Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
Written and peer reviewed by outstanding scientists in their respective fields
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